EAF2

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene.[5][6][7] It is part of the EAF family of proteins.

EAF2
Identifiers
Aliases	EAF2, BM040, TRAITS, U19, ELL associated factor 2
External IDs	OMIM: 607659 MGI: 2146616 HomoloGene: 10208 GeneCards: EAF2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.33 Start 121,835,183 bp[1] End 121,886,526 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 36,792,884 bp[2] End 36,875,003 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001948 protein binding Cellular component • nuclear speck • transcription elongation factor complex • ELL-EAF complex • cell nucleus • nucleoplasm Biological process • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of cell growth • negative regulation of epithelial cell proliferation involved in prostate gland development • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • apoptotic process • transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55840	106389
Ensembl	ENSG00000145088	ENSMUSG00000022838
UniProt	Q96CJ1	Q91ZD6
RefSeq (mRNA)	NM_018456 NM_001320041	NM_001113401 NM_001113405 NM_134111 NM_001358102
RefSeq (protein)	NP_001306970 NP_060926	NP_001106872 NP_001106876 NP_598872 NP_001345031
Location (UCSC)	Chr 3: 121.84 – 121.89 Mb	Chr 16: 36.79 – 36.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000145088 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022838 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Simone F, Luo RT, Polak PE, Kaberlein JJ, Thirman MJ (Feb 2003). "ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties". Blood. 101 (6): 2355–62. doi:10.1182/blood-2002-06-1664. PMID 12446457.
6. Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski JM, Wang Z (Aug 2003). "Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer". Cancer Res. 63 (15): 4698–704. PMID 12907652.
7. "Entrez Gene: EAF2 ELL associated factor 2".

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Saso K, Ito T, Natori S, Sekimizu K (2004). "Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II". J. Biochem. 133 (4): 493–500. doi:10.1093/jb/mvg065. PMID 12761297.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kong SE, Banks CA, Shilatifard A, et al. (2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10094–8. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
• Xiao W, Jiang F, Wang Z (2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057.
• Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.