EAF1

ELL-associated factor 1 is a protein that, in humans, is encoded by the EAF1 gene.[4][5] It is part of the EAF family of proteins.

EAF1
Identifiers
Aliases	EAF1, ELL associated factor 1
External IDs	OMIM: 608315 MGI: 1921677 HomoloGene: 12561 GeneCards: EAF1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 15,427,598 bp[1] End 15,450,635 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • Cajal body • nuclear speck • transcription elongation factor complex • ELL-EAF complex • intracellular membrane-bounded organelle • intercellular bridge • cell nucleus • nucleoplasm • nuclear body Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85403	74427
Ensembl	ENSG00000144597	n/a
UniProt	Q96JC9	Q9D4C5
RefSeq (mRNA)	NM_033083	NM_028932
RefSeq (protein)	NP_149074	NP_083208
Location (UCSC)	Chr 3: 15.43 – 15.45 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000144597 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein". Blood. 98 (1): 201–9. doi:10.1182/blood.V98.1.201. PMID 11418481.
5. "Entrez Gene: EAF1 ELL associated factor 1".

Further reading

• Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003). "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia". Molecular Biology of the Cell. 14 (4): 1517–28. doi:10.1091/mbc.E02-07-0394. PMC 153119. PMID 12686606.
• Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005). "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL". Proceedings of the National Academy of Sciences of the United States of America. 102 (29): 10094–8. doi:10.1073/pnas.0503017102. PMC 1177379. PMID 16006523.
• Xiao W, Jiang F, Wang Z (January 2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation". The Prostate. 66 (1): 1–12. doi:10.1002/pros.20309. PMID 16114057.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Jiang F, Ai J, Xiao W, Wang Z (August 2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Letters. 253 (2): 265–72. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.