Diphoterine

Diphoterine is a sterile washing solution used for the emergency management of chemical spills to the eyes and body.

Emergency eye-wash containing Diphoterine

Mechanism of action

Diphoterine contains an amphoteric, chelating molecule a substance which is capable of reacting with both acids and alkalis. When applied to either type of chemical spill, stopping the aggressive action of a corrosive or irritant chemical, halting the reaction with the body.

However, it is not fully effective at halting the body's reaction with hydrofluoric acid. This is because hydrofluoric acid is poisonous as well as corrosive. A different solution, Hexafluorine, is required to deal with hydrofluoric acid contamination.

Effectiveness

Efficacy has been shown in studies in a clinical setting[1] and also in studies on animals[2].

References
  1. Zack-Williams, S. D., Ahmad, Z., & Moiemen, N. S. (2015). The clinical efficacy of Diphoterine® in the management of cutaneous chemical burns: a 2-year evaluation study. Annals of burns and fire disasters, 28(1), 9–12.
  2. A prospective, randomized, blind comparison between saline, calcium gluconate and diphoterin for washing skin acid injuries in rats: effects on substance P and β-endorphin release
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