DNA damage-binding protein

DNA damage-binding protein or UV-DDB[1] is a protein complex that is responsible for repair of UV-damaged DNA.[2] This complex is composed of two protein subunits, a large subunit DDB1 (p127) and a small subunit DDB2 (p48). When cells are exposed to UV radiation, DDB1 moves from the cytosol to the nucleus and binds to DDB2, thus forming the UV-DDB complex. This complex functions in nucleotide excision repair, recognising UV-induced (6-4) pyrimidine-pyrimidone photoproducts and cyclobutane pyrimidine dimers.[1]

damage-specific DNA binding protein 1, 127kDa
Identifiers
SymbolDDB1
Alt. symbolsXPE
NCBI gene1642
HGNC2717
OMIM600045
RefSeqNM_001923
UniProtQ16531
Other data
LocusChr. 11 q12-q13
damage-specific DNA binding protein 2, 48kDa
Identifiers
SymbolDDB2
Alt. symbolsDBB, UV-DDB2, FLJ34321
NCBI gene1643
HGNC2718
OMIM600811
RefSeqNM_000107
UniProtQ92466
Other data
LocusChr. 11 p12-p11

References

  1. Iovine, Barbara; Iannella, Maria Luigia; Bevilacqua, Maria Assunta (2011). "Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions" (PDF). The International Journal of Biochemistry & Cell Biology. Elsevier. 43: 1664–1667. doi:10.1016/j.biocel.2011.09.001. PMID 21959250.
  2. Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (Feb 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62–9. doi:10.1006/geno.1995.1215. PMID 8530102.


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