DGKZ

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.[5][6]

DGKZ
Identifiers
AliasesDGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta
External IDsOMIM: 601441 MGI: 1278339 HomoloGene: 37831 GeneCards: DGKZ
EC number2.7.1.107
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p11.2Start46,332,905 bp[1]
End46,380,554 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8525

104418

Ensembl

ENSG00000149091

ENSMUSG00000040479

UniProt

Q13574

Q80UP3

RefSeq (mRNA)

NM_001166597
NM_138306

RefSeq (protein)

NP_001160069
NP_612179

Location (UCSC)Chr 11: 46.33 – 46.38 MbChr 2: 91.93 – 91.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[6]

Interactions

DGKZ has been shown to interact with P110α.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000149091 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040479 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J Biol Chem. 271 (17): 10230–6. doi:10.1074/jbc.271.17.10230. PMID 8626588.
  6. "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa".
  7. Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. 278 (41): 39542–7. doi:10.1074/jbc.M307153200. ISSN 0021-9258. PMID 12890670.

Further reading


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