DDX47

Probable ATP-dependent RNA helicase DDX47 is an enzyme that in humans is encoded by the DDX47 gene.[5]

DDX47
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BER
Identifiers
Aliases	DDX47, E4-DBP, HQ0256, MSTP162, RRP3, DEAD-box helicase 47
External IDs	OMIM: 615428 MGI: 1915005 HomoloGene: 6092 GeneCards: DDX47
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 12,813,316 bp[1] End 12,829,981 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 135,011,612 bp[2] End 135,023,776 bp[2]
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • hydrolase activity • ATP binding • GO:0008026 helicase activity • nucleic acid binding • RNA binding Cellular component • nucleolus • membrane • cell nucleus • nucleoplasm • cytoplasm Biological process • mRNA processing • extrinsic apoptotic signaling pathway via death domain receptors • RNA secondary structure unwinding • RNA splicing • apoptotic process • rRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51202	67755
Ensembl	ENSG00000213782	ENSMUSG00000030204
UniProt	Q9H0S4	Q9CWX9
RefSeq (mRNA)	NM_201224 NM_016355	NM_026360
RefSeq (protein)	NP_057439 NP_957518	NP_080636
Location (UCSC)	Chr 12: 12.81 – 12.83 Mb	Chr 6: 135.01 – 135.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000213782 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030204 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Doorbar J, Elston RC, Napthine S, et al. (2000). "The E1∧E4 Protein of Human Papillomavirus Type 16 Associates with a Putative RNA Helicase through Sequences in Its C Terminus". J. Virol. 74 (21): 10081–95. doi:10.1128/JVI.74.21.10081-10095.2000. PMC 102047. PMID 11024137.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Regard JB, Scheek S, Borbiev T, et al. (2004). "Verge: a novel vascular early response gene". J. Neurosci. 24 (16): 4092–103. doi:10.1523/JNEUROSCI.4252-03.2004. PMID 15102925.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Lee JH, Rho SB, Chun T (2005). "GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47)". Biotechnol. Lett. 27 (9): 623–8. doi:10.1007/s10529-005-3628-2. PMID 15977068.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.