DDX21

Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.[5][6]

DDX21
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDDX21, GUA, GURDB, RH-II/GU, RH-II/GuA, DEAD-box helicase 21, DExD-box helicase 21
External IDsOMIM: 606357 MGI: 1860494 HomoloGene: 3473 GeneCards: DDX21
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q22.1Start68,956,170 bp[1]
End68,985,068 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9188

56200

Ensembl

ENSG00000165732

ENSMUSG00000020075

UniProt

Q9NR30

Q9JIK5

RefSeq (mRNA)

NM_001256910
NM_004728

NM_019553

RefSeq (protein)

NP_001243839
NP_004719

NP_062426

Location (UCSC)Chr 10: 68.96 – 68.99 MbChr 10: 62.58 – 62.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.[6]

Interactions

DDX21 has been shown to interact with C-jun.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000165732 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020075 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Valdez BC, Henning D, Busch RK, Woods K, Flores-Rozas H, Hurwitz J, Perlaky L, Busch H (Jun 1996). "A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease". Nucleic Acids Res. 24 (7): 1220–4. doi:10.1093/nar/24.7.1220. PMC 145780. PMID 8614622.
  6. "Entrez Gene: DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21".
  7. Westermarck J, Weiss C, Saffrich R, Kast J, Musti AM, Wessely M, Ansorge W, Séraphin B, Wilm M, Valdez BC, Bohmann D (Feb 2002). "The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription". EMBO J. 21 (3): 451–60. doi:10.1093/emboj/21.3.451. PMC 125820. PMID 11823437.

Further reading


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