Cdc42 binding protein kinase beta

CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene. [5]

CDC42BPB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QFV, 3TKU, 4UAK, 4UAL
Identifiers
Aliases	CDC42BPB, MRCKB, CDC42 binding protein kinase beta
External IDs	OMIM: 614062 MGI: 2136459 HomoloGene: 55945 GeneCards: CDC42BPB
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.32 Start 102,932,380 bp[1] End 103,057,549 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 60.94 cM Start 111,292,976 bp[2] End 111,377,718 bp[2]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • Rho GTPase binding • ATP binding • magnesium ion binding • GO:0032403 macromolecular complex binding • GO:0001948 protein binding Cellular component • cytoplasm • membrane • intercellular junction • cell membrane • cell junction • cell leading edge • actomyosin • cytoskeleton • extracellular exosome • lamellipodium • cell projection Biological process • GO:0007243 intracellular signal transduction • phosphorylation • actomyosin structure organization • establishment or maintenance of cell polarity • protein phosphorylation • cytoskeleton organization • cell migration • signal transduction • actin cytoskeleton organization • actin cytoskeleton reorganization • peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9578	217866
Ensembl	ENSG00000198752	ENSMUSG00000021279
UniProt	Q9Y5S2 Q86XZ8	Q7TT50
RefSeq (mRNA)	NM_006035	NM_183016
RefSeq (protein)	NP_006026 NP_006026.3	NP_898837
Location (UCSC)	Chr 14: 102.93 – 103.06 Mb	Chr 12: 111.29 – 111.38 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rats suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization.

References

1. GRCh38: Ensembl release 89: ENSG00000198752 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021279 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CDC42 binding protein kinase beta". Retrieved 2017-05-31.

Further reading

• Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM (2008). "Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta". J. Biol. Chem. 283 (16): 10543–9. doi:10.1074/jbc.M707463200. PMC 2447637. PMID 18263588.
• Kim YJ, Kim NY, Lee MK, Choi HJ, Baek HJ, Nam CH (2010). "Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients". Exp. Mol. Med. 42 (5): 319–26. doi:10.3858/emm.2010.42.5.030. PMC 2877252. PMID 20177145.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M (2011). "Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration". EMBO J. 30 (4): 665–78. doi:10.1038/emboj.2010.353. PMC 3041950. PMID 21240187.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.