Carbonic anhydrase 5A, mitochondrial

Carbonic anhydrase 5A, mitochondrial is a protein that in humans is encoded by the CA5A gene.[5]

CA5A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA5A, CA5, CA5AD, CAV, CAVA, GS1-21A4.1, carbonic anhydrase 5A
External IDsOMIM: 114761 MGI: 101946 HomoloGene: 68200 GeneCards: CA5A
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q24.2Start87,881,546 bp[1]
End87,936,580 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

763

12352

Ensembl

ENSG00000174990

ENSMUSG00000025317

UniProt

P35218

P23589

RefSeq (mRNA)

NM_001739
NM_001367225

NM_007608

RefSeq (protein)

NP_001730

NP_031634

Location (UCSC)Chr 16: 87.88 – 87.94 MbChr 8: 121.92 – 121.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Carbonic anhydrases (CAs) are a family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA5A is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008].

References

  1. GRCh38: Ensembl release 89: ENSG00000174990 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025317 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Carbonic anhydrase 5A". Retrieved 2019-12-31.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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