Calcium-regulated heat stable protein 1

Calcium-regulated heat stable protein 1 (CARHSP1) also known as calcium-regulated heat-stable protein of 24 kDa (CRHSP-24) is a protein that in humans is encoded by the CARHSP1 gene.[5][6]

CARHSP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AQQ
Identifiers
Aliases	CARHSP1, CRHSP-24, CSDC1, CRHSP24, calcium regulated heat stable protein 1
External IDs	OMIM: 616885 MGI: 1196368 HomoloGene: 8632 GeneCards: CARHSP1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.2 Start 8,852,942 bp[1] End 8,869,012 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 4.26 cM Start 8,658,580 bp[2] End 8,672,155 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • mRNA 3'-UTR binding • DNA binding • phosphatase binding • GO:0001948 protein binding • RNA binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasmic exosome (RNase complex) • cytosol • P-body • P granule • cytoplasm Biological process • GO:0007243 intracellular signal transduction • regulation of transcription, DNA-templated • regulation of mRNA stability • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23589	52502
Ensembl	ENSG00000153048	ENSMUSG00000008393
UniProt	Q9Y2V2	Q9CR86
RefSeq (mRNA)	NM_001042476 NM_001278260 NM_001278261 NM_001278262 NM_001278263 NM_001278264 NM_001278265 NM_001278266 NM_014316	NM_025821
RefSeq (protein)	NP_001035941 NP_001265189 NP_001265190 NP_001265191 NP_001265192 NP_001265193 NP_001265194 NP_001265195 NP_055131	NP_080097
Location (UCSC)	Chr 16: 8.85 – 8.87 Mb	Chr 16: 8.66 – 8.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000153048 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008393 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Groblewski GE, Yoshida M, Bragado MJ, Ernst SA, Leykam J, Williams JA (Sep 1998). "Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells". J Biol Chem. 273 (35): 22738–44. doi:10.1074/jbc.273.35.22738. PMID 9712905.
6. "Entrez Gene: CARHSP1 calcium regulated heat stable protein 1, 24kDa".

Further reading

• Wishart MJ, Dixon JE (2002). "The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production". Proc. Natl. Acad. Sci. U.S.A. 99 (4): 2112–7. doi:10.1073/pnas.251686198. PMC 122327. PMID 11842224.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Schäfer C, Steffen H, Krzykowski KJ, et al. (2003). "CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (4): G726–34. doi:10.1152/ajpgi.00111.2003. PMID 12801884.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.