CRYZL1

Quinone oxidoreductase-like protein 1 is an enzyme that in humans is encoded by the CRYZL1 gene.[5][6]

CRYZL1
Identifiers
Aliases	CRYZL1, 4P11, QOH-1, crystallin zeta like 1
External IDs	OMIM: 603920 MGI: 1913859 HomoloGene: 3749 GeneCards: CRYZL1
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,589,341 bp[1] End 33,643,926 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 91,689,322 bp[2] End 91,728,975 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • NADP binding • NADPH:quinone reductase activity Cellular component • cytosol Biological process • oxidation-reduction process • quinone metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9946	66609
Ensembl	ENSG00000205758	ENSMUSG00000058240
UniProt	O95825	Q921W4
RefSeq (mRNA)	NM_145858 NM_145311	NM_026994 NM_133679
RefSeq (protein)	NP_665857	NP_081270 NP_598440
Location (UCSC)	Chr 21: 33.59 – 33.64 Mb	Chr 16: 91.69 – 91.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000205758 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058240 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J (Jun 1999). "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1". Genomics. 57 (1): 156–9. doi:10.1006/geno.1998.5714. PMID 10191096.
6. "Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1".

External links

• Human CRYZL1 genome location and CRYZL1 gene details page in the UCSC Genome Browser.

Further reading

• Mount SM (2000). "Genomic Sequence, Splicing, and Gene Annotation". Am. J. Hum. Genet. 67 (4): 788–92. doi:10.1086/303098. PMC 1287883. PMID 10986039.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Fernández MR, Porté S, Crosas E, et al. (2007). "Human and yeast zeta-crystallins bind AU-rich elements in RNA". Cell. Mol. Life Sci. 64 (11): 1419–27. doi:10.1007/s00018-007-7091-1. PMID 17497241.