CRIP2

Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.[3][4][5][6]

CRIP2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CU8
Identifiers
Aliases	CRIP2, CRIP, CRP2, ESP1, cysteine rich protein 2
External IDs	OMIM: 601183 HomoloGene: 135666 GeneCards: CRIP2
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 105,472,962 bp[1] End 105,480,170 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • zinc ion binding • GO:0001948 protein binding Cellular component • cell cortex Biological process • positive regulation of cell proliferation • haematopoiesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1397	n/a
Ensembl	ENSG00000182809	n/a
UniProt	P52943	n/a
RefSeq (mRNA)	NM_001270837 NM_001270841 NM_001312	n/a
RefSeq (protein)	NP_001257766 NP_001257770 NP_001303	n/a
Location (UCSC)	Chr 14: 105.47 – 105.48 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000182809 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int. 39 (4): 747–54. PMID 8843343.
4. Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
5. Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem. 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.
6. "Entrez Gene: CRIP2 cysteine-rich protein 2".
7. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.

External links

• Human CRIP2 genome location and CRIP2 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• van Ham M, Croes H, Schepens J, et al. (2004). "Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL". Genes Cells. 8 (7): 631–44. doi:10.1046/j.1365-2443.2003.00660.x. PMID 12839623.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.