CRHBP

Corticotropin-releasing factor-binding protein is a protein that in humans is encoded by the CRHBP gene.[5][6] It belongs to corticotropin-releasing hormone binding protein family.

CRHBP
Identifiers
Aliases	CRHBP, CRF-BP, CRFBP, corticotropin releasing hormone binding protein
External IDs	OMIM: 122559 MGI: 88497 HomoloGene: 1418 GeneCards: CRHBP
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 76,953,045 bp[1] End 76,981,158 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 49.5 cM Start 95,431,371 bp[2] End 95,444,924 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • corticotropin-releasing hormone binding • GO:0001948 protein binding • peptide binding Cellular component • Golgi apparatus • secretory granule • endoplasmic reticulum • perikaryon • axon terminus • dense core granule • dendrite • varicosity • secondary lysosome • multivesicular body • microtubule • extracellular region • extracellular • intracellular • cell nucleus Biological process • negative regulation of corticotropin secretion • female pregnancy • cellular response to tumor necrosis factor • regulation of corticotropin secretion • cellular response to estrogen stimulus • hormone-mediated signaling pathway • behavioral response to ethanol • learning or memory • regulated exocytosis • inflammatory response • signal transduction • cellular response to potassium ion • cellular response to cocaine • negative regulation of corticotropin-releasing hormone receptor activity • synaptic transmission, dopaminergic • maternal aggressive behavior • cellular response to drug • hormone metabolic process • cellular response to calcium ion • cellular response to cAMP • cellular response to estradiol stimulus • cellular response to gonadotropin-releasing hormone • regulation of NMDA receptor activity • regulation of cellular response to stress Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1393	12919
Ensembl	ENSG00000145708	ENSMUSG00000021680
UniProt	P24387	Q60571
RefSeq (mRNA)	NM_001882	NM_198408
RefSeq (protein)	NP_001873	NP_940800
Location (UCSC)	Chr 5: 76.95 – 76.98 Mb	Chr 13: 95.43 – 95.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000145708 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021680 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW (Jun 1993). "Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)" (PDF). Genomics. 16 (1): 63–8. doi:10.1006/geno.1993.1141. PMID 8198617.
6. "Entrez Gene: CRHBP corticotropin releasing hormone binding protein".

External links

• Human CRHBP genome location and CRHBP gene details page in the UCSC Genome Browser.

Further reading

• Behan DP, De Souza EB, Lowry PJ, et al. (1996). "Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides". Frontiers in Neuroendocrinology. 16 (4): 362–82. doi:10.1006/frne.1995.1013. PMID 8557170.
• Westphal NJ, Seasholtz AF (2006). "CRH-BP: the regulation and function of a phylogenetically conserved binding protein". Front. Biosci. 11: 1878–91. doi:10.2741/1931. PMID 16368564.
• Potter E, Behan DP, Fischer WH, et al. (1991). "Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins". Nature. 349 (6308): 423–6. doi:10.1038/349423a0. PMID 1846945.
• Behan DP, Linton EA, Lowry PJ (1989). "Isolation of the human plasma corticotrophin-releasing factor-binding protein". J. Endocrinol. 122 (1): 23–31. doi:10.1677/joe.0.1220023. PMID 2549150.
• Behan DP, Heinrichs SC, Troncoso JC, et al. (1995). "Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease". Nature. 378 (6554): 284–7. doi:10.1038/378284a0. PMID 7477348.
• Vamvakopoulos NC, Sioutopoulou TO, Durkin SA, et al. (1995). "Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3)". Genomics. 25 (1): 325–7. doi:10.1016/0888-7543(95)80151-B. PMID 7774945.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Fischer WH, Behan DP, Park M, et al. (1994). "Assignment of disulfide bonds in corticotropin-releasing factor-binding protein". J. Biol. Chem. 269 (6): 4313–6. PMID 8307998.
• Donaldson CJ, Sutton SW, Perrin MH, et al. (1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563.
• Asakura H, Zwain IH, Yen SS (1997). "Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary". J. Clin. Endocrinol. Metab. 82 (8): 2720–5. doi:10.1210/jc.82.8.2720. PMID 9253360.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wetzka B, Sehringer B, Schäfer WR, et al. (2004). "Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term". Exp. Clin. Endocrinol. Diabetes. 111 (3): 154–61. doi:10.1055/s-2003-39778. PMID 12784189.
• Claes S, Villafuerte S, Forsgren T, et al. (2003). "The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden". Biol. Psychiatry. 54 (9): 867–72. doi:10.1016/S0006-3223(03)00425-6. PMID 14573312.
• Sehringer B, Zahradnik HP, Simon M, et al. (2005). "mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR". J. Mol. Endocrinol. 32 (2): 339–48. doi:10.1677/jme.0.0320339. PMID 15072543.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Herringa RJ, Roseboom PH, Kalin NH (2006). "Decreased amygdala CRF-binding protein mRNA in post-mortem tissue from male but not female bipolar and schizophrenic subjects". Neuropsychopharmacology. 31 (8): 1822–31. doi:10.1038/sj.npp.1301038. PMID 16482088.