CRACR2A

Calcium release activated channel regulator 2A is a protein that in humans is encoded by the CRACR2A gene. [5]

CRACR2A
Identifiers
Aliases	CRACR2A, EFCAB4B, calcium release activated channel regulator 2A
External IDs	OMIM: 614178 MGI: 2685919 HomoloGene: 41883 GeneCards: CRACR2A
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.32 Start 3,606,633 bp[1] End 3,764,819 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 127,561,338 bp[2] End 127,674,248 bp[2]
Gene ontology Molecular function • metal ion binding • calcium ion binding • GO:0001948 protein binding Cellular component • cytoplasm • membrane • extracellular region • specific granule lumen Biological process • ion transport • adaptive immune response • activation of store-operated calcium channel activity • calcium ion transport • store-operated calcium entry • positive regulation of calcium ion transport • immune system process • neutrophil degranulation • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84766	381812
Ensembl	ENSG00000130038	ENSMUSG00000061414
UniProt	Q9BSW2	Q3UP38
RefSeq (mRNA)	NM_001144958 NM_001144959 NM_032680	NM_001033464 NM_001368877
RefSeq (protein)	NP_001138430 NP_116069	NP_001028636 NP_001355806
Location (UCSC)	Chr 12: 3.61 – 3.76 Mb	Chr 6: 127.56 – 127.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000130038 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061414 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Calcium release activated channel regulator 2A". Retrieved 2017-01-30.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge J, Gwack Y (2010). "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells". Nat. Cell Biol. 12 (5): 436–46. doi:10.1038/ncb2045. PMC 2875865. PMID 20418871.
• Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, Cui J, Taylor KD, Wilson L, Cummings OW, Chen YD, Rotter JI (2010). "Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease". Gastroenterology. 139 (5): 1567–76, 1576.e1–6. doi:10.1053/j.gastro.2010.07.057. PMC 2967576. PMID 20708005.