CPSF7

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.[5][6]

CPSF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N9U
Identifiers
Aliases	CPSF7, CFIm59, FLJ12529, cleavage and polyadenylation specific factor 7
External IDs	MGI: 1917826 HomoloGene: 11731 GeneCards: CPSF7
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.2 Start 61,402,641 bp[1] End 61,430,031 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 10,525,266 bp[2] End 10,547,653 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleic acid binding • RNA binding Cellular component • membrane • cell nucleus • nucleoplasm • mRNA cleavage factor complex • cytoplasm • mRNA cleavage and polyadenylation specificity factor complex Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • mRNA 3'-end processing • protein tetramerization • protein heterotetramerization • pre-mRNA cleavage required for polyadenylation • mRNA alternative polyadenylation • messenger ribonucleoprotein complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79869	269061
Ensembl	ENSG00000149532	ENSMUSG00000034820
UniProt	Q8N684	Q8BTV2
RefSeq (mRNA)	NM_001136040 NM_001142565 NM_024811	NM_001164272 NM_172302 NM_001362450
RefSeq (protein)	NP_001129512 NP_001136037 NP_079087	NP_001157744 NP_758506 NP_001349379
Location (UCSC)	Chr 11: 61.4 – 61.43 Mb	Chr 19: 10.53 – 10.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. [7] CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

References

1. GRCh38: Ensembl release 89: ENSG00000149532 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034820 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
7. Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Rüegsegger U, Beyer K, Keller W (March 1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". The Journal of Biological Chemistry. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.