CNPY2

Canopy FGF signaling regulator 2 is a protein that in humans is encoded by the CNPY2 gene.[5]

CNPY2
Identifiers
Aliases	CNPY2, HP10390, MSAP, TMEM4, ZSIG9, canopy FGF signaling regulator 2
External IDs	OMIM: 605861 MGI: 1928477 HomoloGene: 40934 GeneCards: CNPY2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,309,842 bp[1] End 56,316,119 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 76.52 cM Start 128,322,459 bp[2] End 128,327,553 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of plasma membrane • endoplasmic reticulum Biological process • positive regulation of low-density lipoprotein particle receptor biosynthetic process • negative regulation of gene expression • regulation of low-density lipoprotein particle clearance • histogenesis • enzyme linked receptor protein signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10330	56530
Ensembl	ENSG00000257727	ENSMUSG00000025381
UniProt	Q9Y2B0	Q9QXT0
RefSeq (mRNA)	NM_014255 NM_001190991	NM_019953
RefSeq (protein)	NP_001177920 NP_055070	NP_064337
Location (UCSC)	Chr 12: 56.31 – 56.32 Mb	Chr 10: 128.32 – 128.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000257727 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025381 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Canopy FGF signaling regulator 2".

Further reading

• Bornhauser BC, Lindholm D (June 2005). "MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain". Cellular and Molecular Life Sciences. 62 (11): 1260–6. doi:10.1007/s00018-005-5055-x. PMID 15905959.
• Bornhauser BC, Olsson PA, Lindholm D (September 2003). "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain". The Journal of Biological Chemistry. 278 (37): 35412–20. doi:10.1074/jbc.M306271200. PMID 12826659.
• Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (March 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
• Do HT, Tselykh TV, Mäkelä J, Ho TH, Olkkonen VM, Bornhauser BC, Korhonen L, Zelcer N, Lindholm D (April 2012). "Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)". The Journal of Biological Chemistry. 287 (16): 12602–11. doi:10.1074/jbc.M112.341248. PMC 3339997. PMID 22378787.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.