CNOT4

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.[5]

CNOT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E4U, 1UR6
Identifiers
Aliases	CNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDs	OMIM: 604911 MGI: 1859026 HomoloGene: 40870 GeneCards: CNOT4
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33 Start 135,361,795 bp[1] End 135,510,127 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 35,022,065 bp[2] End 35,133,724 bp[2]
Gene ontology Molecular function • ubiquitin-protein transferase activity • GO:0001948 protein binding • nucleic acid binding • metal ion binding • transferase activity • RNA binding Cellular component • cytosol • cytoplasm • CCR4-NOT complex • cell nucleus Biological process • protein ubiquitination • nuclear-transcribed mRNA poly(A) tail shortening • protein autoubiquitination • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • ubiquitin-dependent protein catabolic process • regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4850	53621
Ensembl	ENSG00000080802	ENSMUSG00000038784
UniProt	O95628	Q8BT14
RefSeq (mRNA)	NM_001008225 NM_001190847 NM_001190848 NM_001190849 NM_001190850 NM_013316	NM_001164411 NM_001164412 NM_001164413 NM_001164414 NM_016877
RefSeq (protein)	NP_001008226 NP_001177776 NP_001177777 NP_001177778 NP_001177779 NP_037448	NP_001157883 NP_001157884 NP_001157885 NP_001157886 NP_058573
Location (UCSC)	Chr 7: 135.36 – 135.51 Mb	Chr 6: 35.02 – 35.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000080802 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038784 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: CCR4-NOT transcription complex, subunit 4".
6. "CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody". www.genecards.org. Retrieved 2019-06-21.

Further reading

• Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal. 26 (3): 1239–50. doi:10.1096/fj.11-195875. PMID 22159038.
• Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
• Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009). "Human Ccr4-Not complexes contain variable deadenylase subunits" (PDF). The Biochemical Journal. 422 (3): 443–53. doi:10.1042/BJ20090500. PMID 19558367.
• Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. 21 (3): 355–64. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
• Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004). "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure. 12 (4): 633–44. doi:10.1016/j.str.2004.03.004. PMID 15062086.
• Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
• Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development. 23 (8): 951–62. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
• Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001). "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry. 276 (13): 10185–90. doi:10.1074/jbc.M009298200. PMID 11087754.
• Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.