CNOT2

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene.[5][6] It is a subunit of the CCR4-Not deadenylase complex.

CNOT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0D, 4C0F, 5FU6, 5FU7
Identifiers
Aliases	CNOT2, CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS
External IDs	OMIM: 604909 MGI: 1919318 HomoloGene: 40953 GeneCards: CNOT2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 70,242,994 bp[1] End 70,355,257 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 116,485,161 bp[2] End 116,581,511 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • poly(A)-specific ribonuclease activity • GO:0001104 transcription cofactor activity • GO:0001948 protein binding • RNA polymerase II transcription corepressor binding Cellular component • cytoplasm • membrane • CCR4-NOT complex • P-body • CCR4-NOT core complex • cell nucleus • cytosol • cell membrane Biological process • nuclear-transcribed mRNA poly(A) tail shortening • negative regulation of translation • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • regulation of stem cell population maintenance • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • multicellular organism development • positive regulation of cytoplasmic mRNA processing body assembly • trophectodermal cell differentiation • gene silencing by RNA • negative regulation of intracellular estrogen receptor signaling pathway • regulation of translation • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4848	72068
Ensembl	ENSG00000111596	ENSMUSG00000020166
UniProt	Q9NZN8	Q8C5L3
RefSeq (mRNA)	NM_001199302 NM_001199303 NM_014515	NM_001037846 NM_001037847 NM_001037848 NM_028082 NM_001359247 NM_001359248 NM_001359249 NM_001359250 NM_001359251 NM_001359252 NM_001359253 NM_001359563
RefSeq (protein)	NP_001186231 NP_001186232 NP_055330	NP_001032935 NP_001032936 NP_001032937 NP_082358 NP_001346176 NP_001346177 NP_001346178 NP_001346179 NP_001346180 NP_001346181 NP_001346182 NP_001346492
Location (UCSC)	Chr 12: 70.24 – 70.36 Mb	Chr 10: 116.49 – 116.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000111596 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020166 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
6. "Entrez Gene: CNOT2 CCR4-NOT transcription complex, subunit 2".

External links

• Human CNOT2 genome location and CNOT2 gene details page in the UCSC Genome Browser.

Further reading

• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zwartjes CG, Jayne S, van den Berg DL, Timmers HT (2004). "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex". J. Biol. Chem. 279 (12): 10848–54. doi:10.1074/jbc.M311747200. PMID 14707134.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shi J, Nelson MA (2005). "The cyclin-dependent kinase 11 interacts with NOT2". Biochem. Biophys. Res. Commun. 334 (4): 1310–6. doi:10.1016/j.bbrc.2005.07.026. PMID 16039607.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Jayne S, Zwartjes CG, van Schaik FM, Timmers HT (2006). "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex". Biochem. J. 398 (3): 461–7. doi:10.1042/BJ20060406. PMC 1559471. PMID 16712523.