CMPK

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene.[4][5]

CMPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TEV
Identifiers
Aliases	CMPK1, CK, CMK, CMPK, UMK, UMP-CMPK, UMPK, cytidine/uridine monophosphate kinase 1
External IDs	OMIM: 191710 MGI: 1913838 HomoloGene: 32308 GeneCards: CMPK1
EC number	2.7.4.6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33 Start 47,333,797 bp[1] End 47,378,839 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • uridylate kinase activity • kinase activity • nucleobase-containing compound kinase activity • uridine kinase activity • nucleoside diphosphate kinase activity • ATP binding • cytidylate kinase activity • nucleoside phosphate kinase activity Cellular component • cytoplasm • cytosol • extracellular exosome • cell nucleus • nucleolus Biological process • nucleobase-containing small molecule interconversion • phosphorylation • nucleoside diphosphate phosphorylation • pyrimidine ribonucleotide biosynthetic process • pyrimidine nucleotide biosynthetic process • 'de novo' pyrimidine nucleobase biosynthetic process • nucleoside triphosphate biosynthetic process • nucleobase-containing compound metabolic process • nucleoside monophosphate phosphorylation • UMP biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51727	66588
Ensembl	ENSG00000162368	n/a
UniProt	P30085	Q9DBP5
RefSeq (mRNA)	NM_001136140 NM_016308 NM_001366135	NM_025647
RefSeq (protein)	NP_001129612 NP_057392 NP_001353064	NP_079923
Location (UCSC)	Chr 1: 47.33 – 47.38 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000162368 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology. 56 (3): 562–9. doi:10.1124/mol.56.3.562. PMID 10462544.
5. EntrezGene 51727
6. Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.

External links

• Human CMPK1 genome location and CMPK1 gene details page in the UCSC Genome Browser.

Further reading

• Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: A reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF (1993). "Human liver protein map: Update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5′ untranslated region". Life Sciences. 69 (20): 2361–70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623.
• Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.
• Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates". European Journal of Biochemistry. 270 (8): 1784–90. doi:10.1046/j.1432-1033.2003.03537.x. PMID 12694191.
• Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A (2004). "Substrate-induced Conformational Changes in Human UMP/CMP Kinase". Journal of Biological Chemistry. 279 (32): 33882–9. doi:10.1074/jbc.M401989200. PMID 15163660.
• Hsu CH, Liou JY, Dutschman GE, Cheng YC (2004). "Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium". Molecular Pharmacology. 67 (3): 806–14. doi:10.1124/mol.104.006098. PMID 15550676.
• Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG (2005). "Beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". Journal of Neurochemistry. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.
• Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D (2007). "Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives – a screening based on affinity for the UMP-CMP binding site". FEBS Journal. 274 (14): 3704–14. doi:10.1111/j.1742-4658.2007.05902.x. PMID 17608725.
• Gagyi C, Bucurenci N, Sîrbu O, Labesse G, Ionescu M, Ofiteru A, Assairi L, Landais S, Danchin A, Bârzu O, Gilles AM (2003). "UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity". European Journal of Biochemistry. 270 (15): 3196–204. doi:10.1046/j.1432-1033.2003.03702.x. PMID 12869195.
• Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM (2007). "Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase". The FEBS Journal. 274 (13): 3363–73. doi:10.1111/j.1742-4658.2007.05870.x. PMID 17542990.