CLDN18

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[4] It belongs to the group of claudins.

CLDN18
Identifiers
Aliases	CLDN18, SFTA5, SFTPJ, claudin 18
External IDs	OMIM: 609210 MGI: 1929209 HomoloGene: 9489 GeneCards: CLDN18
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 137,998,735 bp[1] End 138,033,655 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • identical protein binding Cellular component • integral component of membrane • cell junction • cell membrane • membrane • bicellular tight junction Biological process • negative regulation of protein localization to nucleus • TNFSF11-mediated signaling pathway • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules • digestive tract development • negative regulation of osteoclast development • negative regulation of bone resorption • response to ethanol Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51208	56492
Ensembl	ENSG00000066405	n/a
UniProt	P56856	P56857
RefSeq (mRNA)	NM_016369 NM_001002026	NM_001194921 NM_001194922 NM_001194923 NM_019815
RefSeq (protein)	NP_001002026 NP_057453	NP_001181850 NP_001181851 NP_001181852 NP_062789
Location (UCSC)	Chr 3: 138 – 138.03 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[5] [supplied by OMIM][4]

Clinical significance

Isoform 2 (Claudin 18.2) is abundant in gastric tumors.[6]

Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000066405 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: CLDN18 claudin 18".
5. Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.
6. Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016

External links

• Human CLDN18 genome location and CLDN18 gene details page in the UCSC Genome Browser.

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Matsuda Y, Semba S, Ueda J, et al. (2007). "Gastric and intestinal claudin expression at the invasive front of gastric carcinoma". Cancer Sci. 98 (7): 1014–9. doi:10.1111/j.1349-7006.2007.00490.x. PMID 17459057.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.