CLDN10

Claudin-10 is a protein that in humans is encoded by the CLDN10 gene.[5][6] It belongs to the group of claudins.

CLDN10
Identifiers
AliasesCLDN10, CPETRL3, OSP-L, claudin 10, OSPL, HELIX
External IDsOMIM: 617579 MGI: 1913101 HomoloGene: 5076 GeneCards: CLDN10
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q32.1Start95,433,604 bp[1]
End95,579,759 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9071

58187

Ensembl

ENSG00000134873

ENSMUSG00000022132

UniProt

P78369

Q9Z0S6

RefSeq (mRNA)

NM_001160100
NM_006984
NM_182848

RefSeq (protein)

NP_001153572
NP_008915
NP_878268

Location (UCSC)Chr 13: 95.43 – 95.58 MbChr 14: 118.79 – 118.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Two alternatively spliced transcript variants that encode different isoforms have been identified for this gene.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000134873 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022132 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ip YC, Cheung ST, Lee YT, Ho JC, Fan ST (Nov 2007). "Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells". Mol Cancer Ther. 6 (11): 2858–67. doi:10.1158/1535-7163.MCT-07-0453. PMID 18025272.
  6. "Entrez Gene: CLDN10 claudin 10".

Further reading


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