CHPF

Chondroitin sulfate synthase 2 is an enzyme that in humans is encoded by the CHPF gene.[5][6][7]

CHPF
Identifiers
Aliases	CHPF, CHSY2, CSS2, chondroitin polymerizing factor
External IDs	OMIM: 610405 MGI: 106576 HomoloGene: 11574 GeneCards: CHPF
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,538,948 bp[1] End 219,543,809 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C4|1 39.14 cM Start 75,474,569 bp[2] End 75,479,307 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • acetylgalactosaminyltransferase activity • GO:0001948 protein binding • metal ion binding • transferase activity, transferring glycosyl groups • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Cellular component • cytoplasm • integral component of membrane • Golgi cisterna membrane • cytosol • Golgi membrane • mitochondrial matrix • Golgi apparatus • mitochondrion • membrane Biological process • chondroitin sulfate biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79586	74241
Ensembl	ENSG00000123989	ENSMUSG00000032997
UniProt	Q8IZ52	Q6IQX7
RefSeq (mRNA)	NM_001195731 NM_024536	NM_001001565 NM_001001566
RefSeq (protein)	NP_001182660 NP_078812	NP_001001565 NP_001001566
Location (UCSC)	Chr 2: 219.54 – 219.54 Mb	Chr 1: 75.47 – 75.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000123989 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032997 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Kitagawa H, Izumikawa T, Uyama T, Sugahara K (Jun 2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization". J Biol Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
7. "Entrez Gene: CHPF chondroitin polymerizing factor".

External links

• Human CHPF genome location and CHPF gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yada T, Gotoh M, Sato T, et al. (2003). "Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities". J. Biol. Chem. 278 (32): 30235–47. doi:10.1074/jbc.M303657200. PMID 12761225.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.