CDIPT

CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.[5][6]

CDIPT
Identifiers
Aliases	CDIPT, PIS, PIS1, CDP-diacylglycerol--inositol 3-phosphatidyltransferase
External IDs	OMIM: 605893 MGI: 105491 HomoloGene: 7159 GeneCards: CDIPT
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,858,357 bp[1] End 29,863,414 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.26 cM Start 126,975,914 bp[2] End 126,980,501 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • phosphotransferase activity, for other substituted phosphate groups • manganese ion binding • alcohol binding • CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity • GO:0001948 protein binding • diacylglycerol binding • carbohydrate binding Cellular component • integral component of membrane • Golgi apparatus • endoplasmic reticulum membrane • membrane • Golgi membrane • cell membrane • endoplasmic reticulum Biological process • lipid metabolism • CDP-diacylglycerol metabolic process • phospholipid biosynthetic process • phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10423	52858
Ensembl	ENSG00000103502	ENSMUSG00000030682
UniProt	O14735	Q8VDP6
RefSeq (mRNA)	NM_001286585 NM_001286586 NM_006319 NM_145752	NM_026638 NM_001347656 NM_001379260
RefSeq (protein)	NP_001273514 NP_001273515 NP_006310 NP_001273514.1 NP_001273515.1 NP_006310.1	NP_001334585 NP_080914 NP_001366189
Location (UCSC)	Chr 16: 29.86 – 29.86 Mb	Chr 7: 126.98 – 126.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of multiple G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000103502 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030682 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lykidis A, Jackson PD, Rock CO, Jackowski S (Jan 1998). "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". J Biol Chem. 272 (52): 33402–9. doi:10.1074/jbc.272.52.33402. PMID 9407135.
6. "Entrez Gene: CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)".

External links

• Human CDIPT genome location and CDIPT gene details page in the UCSC Genome Browser.

Further reading

• Antonsson B (1997). "Phosphatidylinositol synthase from mammalian tissues". Biochim. Biophys. Acta. 1348 (1–2): 179–86. doi:10.1016/s0005-2760(97)00105-7. PMID 9370331.
• Antonsson BE (1994). "Purification and characterization of phosphatidylinositol synthase from human placenta". Biochem. J. 297 (Pt 3): 517–22. PMC 1137864. PMID 8110188.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• de Serres FJ, Luisetti M, Ferrarotti I, et al. (2005). "Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles". Monaldi Archives for Chest Disease. 63 (3): 133–41. PMID 16312203.