CD5L

CD5 antigen-like is a protein that in humans is encoded by the CD5L gene.[5][6]

CD5L
Identifiers
Aliases	CD5L, AIM, API6, PRO229, SP-ALPHA, Spalpha, CT-2, hAIM, CD5 molecule like
External IDs	OMIM: 602592 MGI: 1334419 HomoloGene: 55936 GeneCards: CD5L
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 157,830,911 bp[1] End 157,898,256 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 87,357,881 bp[2] End 87,371,073 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • scavenger receptor activity Cellular component • cytoplasm • extracellular region • extracellular exosome • blood microparticle • membrane • extracellular • cell membrane • cell surface Biological process • cellular defense response • inflammatory response • receptor-mediated endocytosis • immune system process • apoptotic process • vesicle-mediated transport • regulation of complement activation • positive regulation of complement-dependent cytotoxicity • endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	922	11801
Ensembl	ENSG00000073754	ENSMUSG00000015854
UniProt	O43866	Q9QWK4
RefSeq (mRNA)	NM_005894 NM_001347698	NM_009690
RefSeq (protein)	NP_001334627 NP_005885	NP_033820
Location (UCSC)	Chr 1: 157.83 – 157.9 Mb	Chr 3: 87.36 – 87.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000073754 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015854 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gebe JA, Kiener PA, Ring HZ, Li X, Francke U, Aruffo A (Apr 1997). "Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins". J Biol Chem. 272 (10): 6151–8. doi:10.1074/jbc.272.10.6151. PMID 9045627.
6. "Entrez Gene: CD5L CD5 molecule-like".

External links

• Human CD5L genome location and CD5L gene details page in the UCSC Genome Browser.

Further reading

• Tissot JD, Schifferli JA, Hochstrasser DF, et al. (1994). "Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide". J. Immunol. Methods. 173 (1): 63–75. doi:10.1016/0022-1759(94)90284-4. PMID 8034987.
• Tissot JD, Sanchez JC, Vuadens F, et al. (2002). "IgM are associated to Sp alpha (CD5 antigen-like)". Electrophoresis. 23 (7–8): 1203–6. doi:10.1002/1522-2683(200204)23:7/8<1203::AID-ELPS1203>3.0.CO;2-1. PMID 11981870.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sarrias MR, Roselló S, Sánchez-Barbero F, et al. (2005). "A role for human Sp alpha as a pattern recognition receptor". J. Biol. Chem. 280 (42): 35391–8. doi:10.1074/jbc.M505042200. PMID 16030018.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.