CCNG1

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.[5][6][7]

CCNG1
Identifiers
Aliases	CCNG1, cyclin G1, CCNG
External IDs	OMIM: 601578 MGI: 102890 HomoloGene: 2995 GeneCards: CCNG1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q34 Start 163,437,569 bp[1] End 163,446,151 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A5 Start 40,748,552 bp[2] End 40,755,311 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • protein kinase binding Cellular component • cell nucleus • nucleoplasm • cyclin-dependent protein kinase holoenzyme complex • cytoplasm Biological process • cell cycle • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cell cycle • cell division • GO:0007067 mitotic cell cycle • protein phosphorylation • regulation of mitotic nuclear division • positive regulation of cell proliferation • positive regulation of cell cycle • mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	900	12450
Ensembl	ENSG00000113328	ENSMUSG00000020326
UniProt	P51959	P51945
RefSeq (mRNA)	NM_004060 NM_199246	NM_009831
RefSeq (protein)	NP_004051 NP_954854 NP_001350944 NP_001350947 NP_001350948 NP_001350949 NP_001350950 NP_001350951 NP_001350952	NP_033961
Location (UCSC)	Chr 5: 163.44 – 163.45 Mb	Chr 11: 40.75 – 40.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.[7]

Interactions

CCNG1 has been shown to interact with:

• Mdm2,[8]
• P16,[8]
• P53,[8] and
• PPP2R4.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000113328 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020326 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Endo Y, Fujita T, Tamura K, Tsuruga H, Nojima H (1996). "Structure and chromosomal assignment of the human cyclin G gene". Genomics. 38 (1): 92–5. doi:10.1006/geno.1996.0598. PMID 8954786.
6. Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.
7. "Entrez Gene: CCNG1 cyclin G1".
8. Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE (Jan 2003). "Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways". Mol. Cancer Res. 1 (3): 195–206. PMID 12556559.
9. Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, Beach D (Nov 1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. 16 (11): 6593–602. doi:10.1128/mcb.16.11.6593. PMC 231661. PMID 8887688.

External links

• Human CCNG1 genome location and CCNG1 gene details page in the UCSC Genome Browser.

Further reading

• Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF (1996). "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression". J. Biol. Chem. 271 (11): 6050–61. doi:10.1074/jbc.271.11.6050. PMID 8626390.
• Kanaoka Y, Kimura SH, Okazaki I, Ikeda M, Nojima H (1997). "GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain". FEBS Lett. 402 (1): 73–80. doi:10.1016/S0014-5793(96)01484-6. PMID 9013862.
• Kato MV (1999). "The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria". Leuk. Lymphoma. 33 (1–2): 181–6. doi:10.3109/10428199909093740. PMID 10194136.
• Reimer CL, Borras AM, Kurdistani SK, Garreau JR, Chung M, Aaronson SA, Lee SW (1999). "Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells". J. Biol. Chem. 274 (16): 11022–9. doi:10.1074/jbc.274.16.11022. PMID 10196184.
• Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi:10.1074/jbc.M111693200. PMID 11956189.
• Jordan-Sciutto KL, Morgan K, Bowser R (1999). "Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease". J. Alzheimers Dis. 1 (6): 409–417. doi:10.3233/jad-1999-1605. PMID 12214116.
• Baek WK, Kim D, Jung N, Yi YW, Kim JM, Cha SD, Bae I, Cho CH (2003). "Increased expression of cyclin G1 in leiomyoma compared with normal myometrium". Am. J. Obstet. Gynecol. 188 (3): 634–9. doi:10.1067/mob.[phone]. PMID 12634633.
• Li JQ, Kubo A, Wu F, Usuki H, Fujita J, Bandoh S, Masaki T, Saoo K, Takeuchi H, Kobayashi S, Imaida K, Maeta H, Ishida T, Kuriyama S (2003). "Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes". Int. J. Oncol. 22 (5): 1101–10. doi:10.3892/ijo.22.5.1101. PMID 12684677.
• Ohtsuka T, Jensen MR, Kim HG, Kim KT, Lee SW (2004). "The negative role of cyclin G in ATM-dependent p53 activation". Oncogene. 23 (31): 5405–8. doi:10.1038/sj.onc.1207693. PMID 15077171.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Seo HR, Lee DH, Lee HJ, Baek M, Bae S, Soh JW, Lee SJ, Kim J, Lee YS (2006). "Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1". Cell Death Differ. 13 (9): 1475–84. doi:10.1038/sj.cdd.4401822. PMID 16322753.
• Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Giovannini C, Ferrazzi E, Grazi GL, Croce CM, Bolondi L, Negrini M (2007). "Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma". Cancer Res. 67 (13): 6092–9. doi:10.1158/0008-5472.CAN-06-4607. PMID 17616664.