Archain 1

Archain 1 is a protein that in humans is encoded by the ARCN1 gene. [4]

ARCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifiers
Aliases	ARCN1, COPD, archain 1, SRMMD
External IDs	OMIM: 600820 MGI: 2387591 HomoloGene: 1250 GeneCards: ARCN1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,572,390 bp[1] End 118,603,033 bp[1]
Gene ontology Molecular function • RNA binding Cellular component • cytosol • membrane • Golgi membrane • COPI-coated vesicle membrane • transport vesicle • endoplasmic reticulum • COPI vesicle coat • cytoplasmic vesicle • COPI-coated vesicle • endoplasmic reticulum membrane • cytoplasm • Golgi apparatus Biological process • retrograde vesicle-mediated transport, Golgi to ER • cerebellar Purkinje cell layer maturation • adult locomotory behavior • ER to Golgi vesicle-mediated transport • Golgi vesicle transport • protein transport • pigmentation • intracellular protein transport • vesicle-mediated transport • transport • Golgi localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	372	213827
Ensembl	ENSG00000095139	n/a
UniProt	P48444	Q5XJY5
RefSeq (mRNA)	NM_001142281 NM_001655	NM_145985
RefSeq (protein)	NP_001135753 NP_001646	NP_666097
Location (UCSC)	Chr 11: 118.57 – 118.6 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or vesicle trafficking.

References

1. GRCh38: Ensembl release 89: ENSG00000095139 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Archain 1". Retrieved 2016-06-22.

Further reading

• Deng K, Gao F, Zheng P, Gong W, Sun Z (2012). "Crystallization and preliminary X-ray analysis of the C-terminal domain of δ-COP, a medium-sized subunit of the COPI complex involved in membrane trafficking". Acta Crystallographica Section F. 68 (Pt 7): 829–31. doi:10.1107/S1744309112022798. PMC 3388933. PMID 22750876.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.