AZI2

5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.[5][6]

AZI2
Identifiers
Aliases	AZI2, AZ2, NAP1, TILP, 5-azacytidine induced 2
External IDs	OMIM: 609916 MGI: 1351332 HomoloGene: 8443 GeneCards: AZI2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p24.1 Start 28,315,003 bp[1] End 28,349,050 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 118,040,499 bp[2] End 118,069,794 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm Biological process • interleukin-6 production • dendritic cell differentiation • cytokine production • tumor necrosis factor production • interferon-alpha production • interferon-gamma production • I-kappaB kinase/NF-kappaB signaling • T cell activation • dendritic cell proliferation • GO:0007067 mitotic cell cycle • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64343	27215
Ensembl	ENSG00000163512	ENSMUSG00000039285
UniProt	Q9H6S1	Q9QYP6
RefSeq (mRNA)	NM_001134432 NM_001134433 NM_001271650 NM_022461	NM_001048146 NM_001286507 NM_001286508 NM_013727
RefSeq (protein)	NP_001127904 NP_001127905 NP_001258579 NP_071906	NP_001041611 NP_001273436 NP_001273437 NP_038755
Location (UCSC)	Chr 3: 28.32 – 28.35 Mb	Chr 9: 118.04 – 118.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000163512 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039285 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.
6. "Entrez Gene: AZI2 5-azacytidine induced 2".

External links

• Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser.

Further reading

• Funami K, Sasai M, Ohba Y, et al. (2007). "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA". J. Immunol. 179 (10): 6867–72. doi:10.4049/jimmunol.179.10.6867. PMID 17982077.
• Sasai M, Shingai M, Funami K, et al. (2007). "NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction". J. Immunol. 177 (12): 8676–83. doi:10.4049/jimmunol.177.12.8676. PMID 17142768.
• Sasai M, Oshiumi H, Matsumoto M, et al. (2005). "Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation". J. Immunol. 174 (1): 27–30. doi:10.4049/jimmunol.174.1.27. PMID 15611223.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Fujita F, Taniguchi Y, Kato T, et al. (2003). "Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.