ATRAID

Apoptosis-related protein 3 is a protein that in humans is encoded by the ATRAID gene.[5][6][7]

ATRAID
Identifiers
Aliases	ATRAID, APR--3, APR-3, APR3, C2orf28, PRO240, p18, HSPC013, all-trans retinoic acid induced differentiation factor
External IDs	MGI: 1918918 HomoloGene: 15412 GeneCards: ATRAID
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,212,027 bp[1] End 27,217,178 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,048,312 bp[2] End 31,054,623 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • molecular function Cellular component • perinuclear region of cytoplasm • integral component of membrane • lysosomal membrane • cell membrane • nuclear envelope • membrane • cell nucleus Biological process • regulation of gene expression • negative regulation of osteoblast proliferation • cell differentiation • positive regulation of osteoblast differentiation • positive regulation of bone mineralization • negative regulation of cellular protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51374	381629
Ensembl	ENSG00000138085	ENSMUSG00000013622
UniProt	Q6UW56	Q6PGD0
RefSeq (mRNA)	NM_080592 NM_001170795 NM_016085	NM_027855 NM_212470
RefSeq (protein)	NP_001164266 NP_057169	NP_082131 NP_997635
Location (UCSC)	Chr 2: 27.21 – 27.22 Mb	Chr 5: 31.05 – 31.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138085 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000013622 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. Zhu F, Yan W, Zhao ZL, Chai YB, Lu F, Wang Q, Peng WD, Yang AG, Wang CJ (Nov 2000). "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes". BioTechniques. 29 (2): 310–3. doi:10.2144/00292st06. PMID 10948432.
7. "Entrez Gene: C2orf28 chromosome 2 open reading frame 28".

External links

• Human ATRAID genome location and ATRAID gene details page in the UCSC Genome Browser.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Yang G, Yu F, Fu H, et al. (2007). "Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB". Mol. Cell. Biochem. 302 (1–2): 187–94. doi:10.1007/s11010-007-9440-7. PMID 17387583.
• Yu F, Yang G, Zhao Z, et al. (2007). "Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1". Biochem. Biophys. Res. Commun. 358 (4): 1041–6. doi:10.1016/j.bbrc.2007.05.049. PMID 17524364.