Asporin

Asporin is a protein that in humans is encoded by the ASPN gene.[5]

ASPN
Identifiers
Aliases	ASPN, OS3, PLAP-1, PLAP1, SLRR1C, asporin
External IDs	OMIM: 608135 MGI: 1913945 HomoloGene: 32357 GeneCards: ASPN
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 92,456,205 bp[1] End 92,482,506 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 49,544,443 bp[2] End 49,567,565 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • protein kinase inhibitor activity • collagen binding • extracellular matrix structural constituent conferring compression resistance Cellular component • cytoplasm • extracellular matrix • proteinaceous extracellular matrix • extracellular region • collagen-containing extracellular matrix Biological process • bone mineralization • biomineral tissue development • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of tooth mineralization • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • negative regulation of JAK-STAT cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54829	66695
Ensembl	ENSG00000106819	ENSMUSG00000021388
UniProt	Q9BXN1	Q99MQ4
RefSeq (mRNA)	NM_017680 NM_001193335	NM_001172481 NM_025711
RefSeq (protein)	NP_001180264 NP_060150	NP_001165952 NP_079987
Location (UCSC)	Chr 9: 92.46 – 92.48 Mb	Chr 13: 49.54 – 49.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).[5]

References

1. GRCh38: Ensembl release 89: ENSG00000106819 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021388 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ASPN asporin".

External links

• Human ASPN genome location and ASPN gene details page in the UCSC Genome Browser.

Further reading

• Lorenzo P, Aspberg A, Onnerfjord P, Bayliss MT, Neame PJ, Heinegard D (Apr 2001). "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". The Journal of Biological Chemistry. 276 (15): 12201–11. doi:10.1074/jbc.M010932200. PMID 11152692.
• Henry SP, Takanosu M, Boyd TC, Mayne PM, Eberspaecher H, Zhou W, de Crombrugghe B, Hook M, Mayne R (Apr 2001). "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family". The Journal of Biological Chemistry. 276 (15): 12212–21. doi:10.1074/jbc.M011290200. PMID 11152695.
• Yamada S, Murakami S, Matoba R, Ozawa Y, Yokokoji T, Nakahira Y, Ikezawa K, Takayama S, Matsubara K, Okada H (Sep 2001). "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene. 275 (2): 279–86. doi:10.1016/S0378-1119(01)00683-7. PMID 11587855.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S (Feb 2005). "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis". Nature Genetics. 37 (2): 138–44. doi:10.1038/ng1496. PMID 15640800.
• Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A (2006). "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians". Arthritis Research & Therapy. 8 (3): R55. doi:10.1186/ar1920. PMC 1526645. PMID 16542493.
• Yamada S, Ozawa Y, Tomoeda M, Matoba R, Matsubara K, Murakami S (May 2006). "Regulation of PLAP-1 expression in periodontal ligament cells". Journal of Dental Research. 85 (5): 447–51. doi:10.1177/154405910608500510. PMID 16632759.
• Jiang Q, Shi D, Yi L, Ikegawa S, Wang Y, Nakamura T, Qiao D, Liu C, Dai J (2007). "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese". Journal of Human Genetics. 51 (12): 1068–72. doi:10.1007/s10038-006-0065-6. PMID 17024313.
• Nakamura T, Shi D, Tzetis M, Rodriguez-Lopez J, Miyamoto Y, Tsezou A, Gonzalez A, Jiang Q, Kamatani N, Loughlin J, Ikegawa S (Jul 2007). "Meta-analysis of association between the ASPN D-repeat and osteoarthritis". Human Molecular Genetics. 16 (14): 1676–81. doi:10.1093/hmg/ddm115. PMID 17517696.
• Shi D, Nakamura T, Dai J, Yi L, Qin J, Chen D, Xu Z, Wang Y, Ikegawa S, Jiang Q (2007). "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population". Journal of Human Genetics. 52 (8): 664–7. doi:10.1007/s10038-007-0166-x. PMID 17603749.
• Kou I, Nakajima M, Ikegawa S (Nov 2007). "Expression and regulation of the osteoarthritis-associated protein asporin". The Journal of Biological Chemistry. 282 (44): 32193–9. doi:10.1074/jbc.M706262200. PMID 17804408.
• Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S (Nov 2007). "Mechanisms for asporin function and regulation in articular cartilage". The Journal of Biological Chemistry. 282 (44): 32185–92. doi:10.1074/jbc.M700522200. PMID 17827158.