ARHGEF2

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.[5][6][7]

ARHGEF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF2, GEF, GEF-H1, GEFH1, LFP40, P40, Rho/Rac guanine nucleotide exchange factor 2, NEDMHM, Lfc
External IDsOMIM: 607560 MGI: 103264 HomoloGene: 3468 GeneCards: ARHGEF2
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q22Start155,946,851 bp[1]
End156,007,070 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9181

16800

Ensembl

ENSG00000116584

ENSMUSG00000028059

UniProt

Q92974

Q60875

RefSeq (mRNA)

NM_001198911
NM_001198912
NM_001198913
NM_008487
NM_001377126

RefSeq (protein)

NP_001185840
NP_001185841
NP_001185842
NP_032513
NP_001364055

Location (UCSC)Chr 1: 155.95 – 156.01 MbChr 3: 88.61 – 88.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals.[7]

Interactions

ARHGEF2 has been shown to interact with PAK1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000116584 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028059 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ren Y, Li R, Zheng Y, Busch H (Feb 1999). "Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases". J Biol Chem. 273 (52): 34954–60. doi:10.1074/jbc.273.52.34954. PMID 9857026.
  6. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  7. "Entrez Gene: ARHGEF2 rho/rac guanine nucleotide exchange factor (GEF) 2".
  8. Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM (Apr 2004). "p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor". J. Biol. Chem. 279 (18): 18392–400. doi:10.1074/jbc.M400084200. PMID 14970201.

Further reading


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