APOF

Apolipoprotein F is a protein that in humans is encoded for by the APOF gene.[4][5]

APOF
Identifiers
Aliases	APOF, Apo-F, LTIP, apolipoprotein F
External IDs	OMIM: 107760 MGI: 104539 HomoloGene: 48030 GeneCards: APOF
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,360,568 bp[1] End 56,362,857 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cholesterol binding • receptor binding • lipid transporter activity Cellular component • low-density lipoprotein particle • high-density lipoprotein particle • extracellular region • extracellular Biological process • steroid metabolic process • lipid transport • cholesterol metabolic process • lipid metabolism Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	319	103161
Ensembl	ENSG00000175336	n/a
UniProt	Q13790	Q91V80
RefSeq (mRNA)	NM_001638	NM_133997
RefSeq (protein)	NP_001629	NP_598758
Location (UCSC)	Chr 12: 56.36 – 56.36 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Apolipoprotein F
Identifiers
Symbol	APOF
Pfam	PF15148
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000175336 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.
5. "Entrez Gene: APOF apolipoprotein F".

External links

• Human APOF genome location and APOF gene details page in the UCSC Genome Browser.

Further reading

• Morton RE, Gnizak HM, Greene DJ, et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects". J. Lipid Res. 49 (1): 127–35. doi:10.1194/jlr.M700258-JLR200. PMID 17901467.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)". J. Biol. Chem. 278 (42): 40859–66. doi:10.1074/jbc.M306580200. PMID 12907677.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F". J. Biol. Chem. 274 (3): 1814–20. doi:10.1074/jbc.274.3.1814. PMID 9880564.
• Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma". Biochemistry. 21 (21): 5347–51. doi:10.1021/bi00264a035. PMID 6816269.
• Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma". Biochemistry. 17 (6): 1032–6. doi:10.1021/bi00599a014. PMID 204339.