APOA1BP

Apolipoprotein A-I-binding protein also known as APOA1BP is a protein that in humans is encoded by the APOA1BP gene.[5]

NAXE
Identifiers
Aliases	NAXE, AIBP, YJEFN1, APOA1BP, NAD(P)HX epimerase, PEBEL
External IDs	OMIM: 608862 MGI: 2180167 HomoloGene: 70948 GeneCards: NAXE
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,591,762 bp[1] End 156,594,299 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,056,520 bp[2] End 88,058,495 bp[2]
Gene ontology Molecular function • nucleotide binding • NADHX epimerase activity • GO:0001948 protein binding • protein homodimerization activity • isomerase activity • metal ion binding • NADPHX epimerase activity Cellular component • cell body • extracellular region • cilium • extracellular exosome • intracellular membrane-bounded organelle • mitochondrion • cell nucleus • nucleoplasm • mitochondrial matrix • extracellular • cytosol Biological process • protein homotetramerization • NAD biosynthesis via nicotinamide riboside salvage pathway • nicotinamide nucleotide metabolic process • NADH metabolic process • NADP metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	128240	246703
Ensembl	ENSG00000163382	ENSMUSG00000028070
UniProt	Q8NCW5	Q8K4Z3
RefSeq (mRNA)	NM_144772	NM_144897
RefSeq (protein)	NP_658985	NP_659146
Location (UCSC)	Chr 1: 156.59 – 156.59 Mb	Chr 3: 88.06 – 88.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

APOA1BP binds to APOA1, APOA2, and high-density lipoprotein (HDL).[5] In addition, APOA1BP appears to play a role in sperm capacitation.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000163382 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028070 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ritter M, Buechler C, Boettcher A, Barlage S, Schmitz-Madry A, Orsó E, Bared SM, Schmiedeknecht G, Baehr CH, Fricker G, Schmitz G (May 2002). "Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I". Genomics. 79 (5): 693–702. doi:10.1006/geno.2002.6761. PMID 11991719.
6. Jha KN, Shumilin IA, Digilio LC, Chertihin O, Zheng H, Schmitz G, Visconti PE, Flickinger CJ, Minor W, Herr JC (May 2008). "Biochemical and Structural Characterization of Apolipoprotein A-I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation". Endocrinology. 149 (5): 2108–20. doi:10.1210/en.2007-0582. PMC 2329272. PMID 18202122.