APBA2BP

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[5][6]

NECAB3
Identifiers
AliasesNECAB3, APBA2BP, EFCBP3, NIP1, STIP3, SYTIP2, XB51, dJ63M2.4, dJ63M2.5, N-terminal EF-hand calcium binding protein 3
External IDsOMIM: 612478 MGI: 1861721 HomoloGene: 10992 GeneCards: NECAB3
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.22Start33,657,087 bp[1]
End33,674,463 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

63941

56846

Ensembl

ENSG00000125967

ENSMUSG00000027489

UniProt

Q96P71

Q9D6J4

RefSeq (mRNA)

NM_031231
NM_031232

NM_021546
NM_001379147
NM_001379148
NM_001379149

RefSeq (protein)

NP_112508
NP_112509

NP_067521
NP_001366076
NP_001366077
NP_001366078

Location (UCSC)Chr 20: 33.66 – 33.67 MbChr 2: 154.54 – 154.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000125967 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027489 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem. 275 (30): 23134–8. doi:10.1074/jbc.C000302200. PMID 10833507.
  6. "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein".

Further reading

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