ALS2CR2

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.[5][6][7]

STRADB
Identifiers
AliasesSTRADB, STE20-related kinase adaptor beta, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038, ALS2CR2, STE20 related adaptor beta
External IDsOMIM: 607333 MGI: 2144047 HomoloGene: 10237 GeneCards: STRADB
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.1Start201,387,858 bp[1]
End201,480,846 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55437

227154

Ensembl

ENSG00000082146

ENSMUSG00000026027

UniProt

Q9C0K7

Q8K4T3

RefSeq (mRNA)

NM_001206864
NM_018571

NM_172656
NM_173155

RefSeq (protein)

NP_001193793
NP_061041

NP_766244

Location (UCSC)Chr 2: 201.39 – 201.48 MbChr 1: 58.97 – 59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.[7]

Interactions

ALS2CR2 has been shown to interact with XIAP.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000082146 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026027 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (January 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
  6. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG (Jul 2004). "Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade". Journal of Biology. 2 (4): 28. doi:10.1186/1475-4924-2-28. PMC 333410. PMID 14511394.
  7. "Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2".
  8. Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (August 2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". The Journal of Biological Chemistry. 277 (34): 30454–62. doi:10.1074/jbc.M203312200. PMID 12048196.

Further reading


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