AKAP5

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.[5][6][7]

AKAP5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKAP5, AKAP75, AKAP79, H21, A-kinase anchoring protein 5
External IDsOMIM: 604688 MGI: 2685104 HomoloGene: 15854 GeneCards: AKAP5
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q23.3Start64,465,499 bp[1]
End64,474,503 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9495

238276

Ensembl

ENSG00000179841

ENSMUSG00000021057

UniProt

P24588
Q6PG46

D3YVF0

RefSeq (mRNA)

NM_004857

NM_001101471

RefSeq (protein)

NP_004848
NP_004848.3

NP_001094941

Location (UCSC)Chr 14: 64.47 – 64.47 MbChr 12: 76.32 – 76.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.[7]

Interactions

AKAP5 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000179841 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021057 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79". J Biol Chem. 267 (24): 16816–23. PMID 1512224.
  6. Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J Biol Chem. 267 (19): 13376–82. PMID 1618839.
  7. "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5".
  8. Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y (Oct 1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region". J. Biol. Chem. 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270.
  9. Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (Jan 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci. 22 (1): 87–97. doi:10.1016/s1044-7431(02)00017-9. PMID 12595241.

Further reading


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