ACTR1B

Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.[5][6][7]

ACTR1B
Identifiers
Aliases	ACTR1B, ARP1B, CTRN2, PC3, ARP1 actin-related protein 1 homolog B, centractin beta, ARP1 actin related protein 1 homolog B, actin related protein 1B
External IDs	OMIM: 605144 MGI: 1917446 HomoloGene: 101541 GeneCards: ACTR1B
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 97,655,939 bp[1] End 97,664,044 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 36,698,114 bp[2] End 36,714,422 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • ATP binding • microtubule cortical anchor activity Cellular component • cytoplasm • microtubule cytoskeleton • cytosol • centrosome • extracellular exosome • cytoskeleton • membrane • dynactin complex • microtubule organizing center • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen • cell cortex region Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class II • neutrophil degranulation • establishment of mitotic spindle orientation • nuclear migration along microtubule Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10120	226977
Ensembl	ENSG00000115073	ENSMUSG00000037351
UniProt	P42025	Q8R5C5
RefSeq (mRNA)	NM_005735	NM_146107
RefSeq (protein)	NP_005726	NP_666219
Location (UCSC)	Chr 2: 97.66 – 97.66 Mb	Chr 1: 36.7 – 36.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000115073 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037351 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (May 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711.
6. Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100.
7. "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".

Further reading

• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1". Mol. Biol. Cell. 14 (7): 2645–54. doi:10.1091/mbc.E03-01-0049. PMC 165665. PMID 12857853.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749.

External links

• ACTR1B human gene location in the UCSC Genome Browser.
• ACTR1B human gene details in the UCSC Genome Browser.