ACSS3

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.[5]

ACSS3
Identifiers
Aliases	ACSS3, acyl-CoA synthetase short-chain family member 3, acyl-CoA synthetase short chain family member 3
External IDs	OMIM: 614356 MGI: 2685720 HomoloGene: 11587 GeneCards: ACSS3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.31 Start 80,936,414 bp[1] End 81,261,210 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 106,933,517 bp[2] End 107,123,668 bp[2]
Gene ontology Molecular function • nucleotide binding • ligase activity • catalytic activity • ATP binding • acetate-CoA ligase activity Cellular component • mitochondrion • mitochondrial matrix Biological process • metabolism • ketone body biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79611	380660
Ensembl	ENSG00000111058	ENSMUSG00000035948
UniProt	Q9H6R3	Q14DH7
RefSeq (mRNA)	NM_024560 NM_001330242 NM_001330243	NM_001142804 NM_198636
RefSeq (protein)	NP_001317171 NP_001317172 NP_078836	NP_001136276 NP_941038
Location (UCSC)	Chr 12: 80.94 – 81.26 Mb	Chr 10: 106.93 – 107.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ACSS3 is part of a family known as Acyl-coenzyme A synthetases (ACSs), which catalyze the initial reaction in fatty acid metabolism. This reaction activates fatty acids via thioesterification to CoA, thereby allowing their participation in both anabolic and catabolic pathways. The existence of many ACSs suggests that each plays a unique role, directing the acyl-CoA product to a specific metabolic fate. Knowing the full complement of ACS genes in the human genome will facilitate future studies to characterize their specific biological functions.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000111058 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035948 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Acyl-CoA synthetase short-chain family member 3".
6. Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Further reading

• Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP (Sep 2013). "A genome-wide association study of a sustained pattern of antidepressant response". Journal of Psychiatric Research. 47 (9): 1157–65. doi:10.1016/j.jpsychires.2013.05.002. PMC 3710535. PMID 23726668.
• Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.