Zinc finger protein 674

Zinc finger protein 674 is a protein that in humans is encoded by the ZNF674 gene. [3]

ZNF674
Identifiers
Aliases	ZNF674, MRX92, ZNF673B, zinc finger protein 674
External IDs	OMIM: 300573 HomoloGene: 87837 GeneCards: ZNF674
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.3 Start 46,497,727 bp[1] End 46,545,457 bp[1]
Gene ontology Molecular function • DNA binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • intracellular • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	641339	n/a
Ensembl	ENSG00000251192	n/a
UniProt	Q2M3X9	n/a
RefSeq (mRNA)	NM_001039891 NM_001146291 NM_001190417	n/a
RefSeq (protein)	NP_001034980 NP_001139763 NP_001177346	n/a
Location (UCSC)	Chr X: 46.5 – 46.55 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants encoding different isoforms.

References

1. GRCh38: Ensembl release 89: ENSG00000251192 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Zinc finger protein 674". Retrieved 2016-03-02.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.