Zinc finger protein 157

Zinc finger protein 157 is a protein that in humans is encoded by the ZNF157 gene. [3]

ZNF157
Identifiers
Aliases	ZNF157, HZF22, zinc finger protein 157
External IDs	OMIM: 300024 HomoloGene: 130519 GeneCards: ZNF157
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.3 Start 47,370,583 bp[1] End 47,414,305 bp[1]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • intracellular • cell nucleus Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7712	n/a
Ensembl	ENSG00000147117	n/a
UniProt	P51786	n/a
RefSeq (mRNA)	NM_003446	n/a
RefSeq (protein)	NP_003437	n/a
Location (UCSC)	Chr X: 47.37 – 47.41 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23.

References

1. GRCh38: Ensembl release 89: ENSG00000147117 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Zinc finger protein 157". Retrieved 2016-03-17.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.