Zerknüllt

Zerknüllt (zen, German for "crumpled") is a gene in the Antennapedia complex of Drosophila (fruit flies), where it operates very differently from homologous genes in other organisms.

Zerknüllt 1
Identifiers
OrganismDrosophila melanogaster
Symbolzen
UniProtP09089
Zerknüllt 2
Identifiers
OrganismDrosophila melanogaster
Symbolzen2
UniProtP09090

Zerknüllt codes for a homeoprotein that helps shape the fly's tissue during embryogenesis. In Drosophila, zerknüllt's expression is repressed by dorsal protein. This normally limits its expression to roughly the dorsal 40% of the embryo, where the concentration of dorsal protein is low. Zerknüllt's homologs are hox genes, common to a vast range of organisms evolutionarily very distant from Drosophila, even including mammals. Hox genes are activated by genetic regulation mechanisms that target each gene's effect much more narrowly: to just one segment of the developing embryo, corresponding to the gene's position in the chromosome sequence.[1][2]

See also

References
  1. Jonathan Michael Wyndham Slack. Essential Developmental Biology, 2nd ed., Wiley-Blackwell (2006). Pages 150, 159.
  2. Schaum's Outline of Theory and Problems of Molecular and Cell Biology, McGraw-Hill Professional (1996). Page 295.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.