ZNRD1

DNA-directed RNA polymerase I subunit RPA12 is an enzyme that in humans is encoded by the ZNRD1 gene.[5][6][7]

POLR1H
Identifiers
Aliases	POLR1H, HTEX-6, Rpa12, TEX6, ZR14, hZR14, tctex-6, HTEX6, TCTEX6, zinc ribbon domain containing 1, RNA polymerase I subunit H, ZNRD1, A12.2
External IDs	OMIM: 607525 MGI: 1913386 HomoloGene: 40960 GeneCards: POLR1H
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 30,058,899 bp[1] End 30,064,909 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 36,954,356 bp[2] End 36,958,559 bp[2]
Gene ontology Molecular function • DNA-directed 5'-3' RNA polymerase activity • zinc ion binding • metal ion binding • nucleic acid binding • RNA polymerase I activity Cellular component • nucleolus • cell nucleus • nucleoplasm • DNA-directed RNA polymerase I complex Biological process • transcription initiation from RNA polymerase I promoter • positive regulation of gene expression, epigenetic • nucleobase-containing compound metabolic process • transcription, DNA-templated • mRNA cleavage • termination of RNA polymerase I transcription • transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30834	66136
Ensembl	ENSG00000206502 ENSG00000224859 ENSG00000235443 ENSG00000236949 ENSG00000235176 ENSG00000233795 ENSG00000236808 ENSG00000066379	ENSMUSG00000036315
UniProt	Q9P1U0 Q2L6J2	Q791N7
RefSeq (mRNA)	NM_001278785 NM_001278786 NM_014596 NM_170783	NM_023162 NM_001355422
RefSeq (protein)	NP_001265714 NP_001265715 NP_055411 NP_740753 NP_001265714.1 NP_001265715.1 NP_055411.1 NP_740753.1	NP_075651 NP_001342351
Location (UCSC)	Chr 6: 30.06 – 30.06 Mb	Chr 17: 36.95 – 36.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with similarity to the Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase I. Alternate splicing of this gene results in two transcript variants encoding the same protein. Additional splice variants have been described, but their full-length sequences have not been determined.[7]

References

1. ENSG00000224859, ENSG00000235443, ENSG00000236949, ENSG00000235176, ENSG00000233795, ENSG00000236808, ENSG00000066379 GRCh38: Ensembl release 89: ENSG00000206502, ENSG00000224859, ENSG00000235443, ENSG00000236949, ENSG00000235176, ENSG00000233795, ENSG00000236808, ENSG00000066379 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036315 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lepourcelet M, Andrieux N, Giffon T, Pichon L, Hampe A, Galibert F, Mosser J (Nov 1996). "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence". Genomics. 37 (3): 316–26. doi:10.1006/geno.1996.0566. PMID 8938444.
6. Fan W, Wang Z, Kyzysztof F, Prange C, Lennon G (Jan 2000). "A new zinc ribbon gene (ZNRD1) is cloned from the human MHC class I region". Genomics. 63 (1): 139–41. doi:10.1006/geno.1999.6040. PMID 10662553.
7. "Entrez Gene: ZNRD1 zinc ribbon domain containing 1".

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Coriton O, Lepourcelet M, Hampe A, Galibert F, Mosser J (Dec 2000). "Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes". Mammalian Genome. 11 (12): 1127–31. doi:10.1007/s003350010213. PMID 11130983.
• Shi Y, Zhang Y, Zhao Y, Hong L, Liu N, Jin X, Pan Y, Fan D (Apr 2004). "Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein". Cancer Biology & Therapy. 3 (4): 377–81. doi:10.4161/cbt.3.4.724. PMID 14726695.
• Hong L, Zhang Y, Liu N, Liu C, Zhi M, Pan Y, Lan M, Sun L, Fan D (Aug 2004). "Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene". Biochemical and Biophysical Research Communications. 321 (3): 611–6. doi:10.1016/j.bbrc.2004.07.007. PMID 15358150.
• Hong L, Han Y, Shi R, Shao X, Sun L, Zhang Y, Huang D, Chen Z, Zhang G, Liang J, Hu S, Fan D (Jan 2005). "ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase". Cancer Biology & Therapy. 4 (1): 60–4. doi:10.4161/cbt.4.1.1375. PMID 15662122.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Hong L, Zhao Y, Han Y, Guo W, Jin H, Qiao T, Che Z, Fan D (Aug 2007). "Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells". Carcinogenesis. 28 (8): 1622–8. doi:10.1093/carcin/bgm064. PMID 17389617.
• Hong L, Wang J, Zhao Y, Han Z, Zhou X, Guo W, Zhang X, Jin H, Wu K, Ding J, Fan D (Dec 2007). "DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1". Cancer Investigation. 25 (8): 699–705. doi:10.1080/07357900701566304. PMID 18058465.