ZMIZ1

Zinc finger MIZ domain-containing protein 1 is a protein that in humans is encoded by the ZMIZ1 gene.[5]

ZMIZ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AIZ
Identifiers
Aliases	ZMIZ1, MIZ, RAI17, TRAFIP10, ZIMP10, hZIMP10, zinc finger MIZ-type containing 1, NEDDFSA
External IDs	OMIM: 607159 MGI: 3040693 HomoloGene: 10667 GeneCards: ZMIZ1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.3 Start 79,068,966 bp[1] End 79,316,528 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 25,459,185 bp[2] End 25,666,743 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • metal ion binding Cellular component • cytoplasm • cell nucleus • nuclear speck • intracellular membrane-bounded organelle • nucleoplasm Biological process • vasculogenesis • cell aging • heart morphogenesis • developmental growth • in utero embryonic development • regulation of transcription, DNA-templated • transcription, DNA-templated • vitellogenesis • artery morphogenesis • positive regulation of fibroblast proliferation • positive regulation of T cell differentiation • positive regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57178	328365
Ensembl	ENSG00000108175	ENSMUSG00000007817
UniProt	Q9ULJ6	Q6P1E1
RefSeq (mRNA)	NM_020338	NM_001033402 NM_183208 NM_001310666
RefSeq (protein)	NP_065071	NP_001297595 NP_899031
Location (UCSC)	Chr 10: 79.07 – 79.32 Mb	Chr 14: 25.46 – 25.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ZMIZ1 has been shown to interact with Androgen receptor.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000108175 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007817 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ZMIZ1 zinc finger, MIZ-type containing 1".
6. Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ, Lim B, Sun Z (Nov 2003). "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci". EMBO J. 22 (22): 6101–6114. doi:10.1093/emboj/cdg585. PMC 275443. PMID 14609956.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–358. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–345. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–3496. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ, Lim B, Sun Z (2004). "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci". EMBO J. 22 (22): 6101–6114. doi:10.1093/emboj/cdg585. PMC 275443. PMID 14609956.
• Li X, Thyssen G, Beliakoff J, Sun Z (2006). "The novel PIAS-like protein hZimp10 enhances Smad transcriptional activity". J. Biol. Chem. 281 (33): 23748–23756. doi:10.1074/jbc.M508365200. PMID 16777850.
• Cappuzzello C, Melchionna R, Mangoni A, Tripodi G, Ferrari P, Torielli L, Arcelli D, Helmer-Citterich M, Bianchi G, Capogrossi MC, Napolitano M (2007). "Role of rat alpha adducin in angiogenesis: null effect of the F316Y polymorphism". Cardiovasc. Res. 75 (3): 608–617. doi:10.1016/j.cardiores.2007.04.020. PMID 17512505.
• Lee J, Beliakoff J, Sun Z (2007). "The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor". Nucleic Acids Res. 35 (13): 4523–4534. doi:10.1093/nar/gkm476. PMC 1935018. PMID 17584785.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9ULJ6 (Zinc finger MIZ domain-containing protein 1) at the PDBe-KB.