ZFYVE20

RBSN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YZM, 1Z0J, 1Z0K
Identifiers
Aliases	RBSN, Rabenosyn-5, ZFYVE20, rabenosyn, RAB effector
External IDs	OMIM: 609511 MGI: 1925537 HomoloGene: 41477 GeneCards: RBSN
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	15,099,163 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	92,214,925 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• zinc ion binding; • metal ion binding; • Rab GTPase binding; • GO:0001948 protein binding; • nucleic acid binding;
Cellular component	• endosome; • early endosome membrane; • intracellular membrane-bounded organelle; • membrane; • cytoplasmic side of endosome membrane; • cell membrane; • endosome membrane; • extracellular exosome; • cytosol;
Biological process	• endosomal vesicle fusion; • endocytosis; • vacuole inheritance; • Golgi to endosome transport; • blood coagulation; • endosomal transport; • protein transport; • regulation of Golgi organization; • Golgi to lysosome transport; • early endosome to Golgi transport; • transport;
	Sources:Amigo / QuickGO
Orthologs
	64145
	78287
	ENSG00000131381
	ENSMUSG00000014550
	Q9H1K0
	Q80Y56
	NM_001302378; NM_022340
	NM_030081
	NP_001289307; NP_071735
	NP_084357
	Wikidata
View/Edit Human	View/Edit Mouse

Rabenosyn-5 is a protein that in humans is encoded by the ZFYVE20 gene.[5][6]

Interactions

ZFYVE20 has been shown to interact with RAB5A.[5]

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gollark: There's a new ATX12VO standard which drops everything but 12V because it's not used much, apparently.

gollark: For now it'd be neat if there were actually good AR glasses available. Google Glass got killed off, and there was this company called North doing similar stuff but... Google bought them and killed them off too.

gollark: Brains are very adaptable, so perhaps you could just dump data into some neurons in some useful format and hope it learns to decode it.

gollark: I'd be *interested* in brain-computer-interface stuff, but it'll probably be a while before it develops into something useful and the security implications are very ææææaa.

References

GRCh38: Ensembl release 89: ENSG00000131381 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000014550 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (Nov 2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". J Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588. PMID 11062261.
"Entrez Gene: ZFYVE20 zinc finger, FYVE domain containing 20".

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Eathiraj S, Pan X, Ritacco C, Lambright DG (2005). "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5". Nature. 436 (7049): 415–9. doi:10.1038/nature03798. PMC 1360218. PMID 16034420.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Naslavsky N, Boehm M, Backlund PS, Caplan S (2005). "Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane". Mol. Biol. Cell. 15 (5): 2410–22. doi:10.1091/mbc.E03-10-0733. PMC 404033. PMID 15020713.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
de Renzis S, Sönnichsen B, Zerial M (2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes". Nat. Cell Biol. 4 (2): 124–33. doi:10.1038/ncb744. PMID 11788822.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131381 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014550 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11062261-5] Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (Nov 2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain". J Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588. PMID 11062261.

[entrez-6] "Entrez Gene: ZFYVE20 zinc finger, FYVE domain containing 20".

ZFYVE20

Interactions

References

Further reading