ZFPM1

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 or FOG1 is a protein that in humans is encoded by the ZFPM1 gene.[5] It is a cofactor of the GATA1 transcription factor.

ZFPM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XU7
Identifiers
Aliases	ZFPM1, FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A, zinc finger protein, FOG family member 1
External IDs	OMIM: 601950 MGI: 1095400 HomoloGene: 7606 GeneCards: ZFPM1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.2 Start 88,453,280 bp[1] End 88,537,031 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 122,282,141 bp[2] End 122,337,251 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription factor binding • transcription factor binding • metal ion binding • RNA polymerase II activating transcription factor binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948 protein binding • nucleic acid binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • transcription factor complex • transcriptional repressor complex • nucleoplasm • cell nucleus Biological process • megakaryocyte development • megakaryocyte differentiation • negative regulation of mast cell differentiation • negative regulation of interleukin-4 biosynthetic process • negative regulation of fat cell differentiation • regulation of transcription, DNA-templated • homeostasis of number of cells • transcriptional activation by promoter-enhancer looping • positive regulation of interferon-gamma biosynthetic process • ventricular septum morphogenesis • outflow tract morphogenesis • platelet formation • blood coagulation • cardiac muscle tissue morphogenesis • negative regulation of transcription from RNA polymerase II promoter • negative regulation of protein binding • transcription, DNA-templated • regulation of chemokine production • atrial septum morphogenesis • heart development • atrioventricular valve morphogenesis • granulocyte differentiation • embryonic hemopoiesis • regulation of definitive erythrocyte differentiation • T-helper cell lineage commitment • primitive erythrocyte differentiation • mitral valve formation • tricuspid valve formation • definitive erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • erythrocyte differentiation • regulation of megakaryocyte differentiation • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	161882	22761
Ensembl	ENSG00000179588	ENSMUSG00000049577
UniProt	Q8IX07	O35615
RefSeq (mRNA)	NM_153813	NM_009569
RefSeq (protein)	NP_722520	NP_033595
Location (UCSC)	Chr 16: 88.45 – 88.54 Mb	Chr 8: 122.28 – 122.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000179588 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049577 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ZFPM1 zinc finger protein, multitype 1".

Further reading

• Tsang AP, Visvader JE, Turner CA, et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation". Cell. 90 (1): 109–19. doi:10.1016/S0092-8674(00)80318-9. PMID 9230307.
• Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
• Mehaffey MG, Newton AL, Gandhi MJ, et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1". Blood. 98 (9): 2681–8. doi:10.1182/blood.V98.9.2681. PMID 11675338.
• Yu C, Niakan KK, Matsushita M, et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction". Blood. 100 (6): 2040–5. doi:10.1182/blood-2002-02-0387. PMC 2808424. PMID 12200364.
• Freson K, Thys C, Wittewrongel C, et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions". Hum. Genet. 112 (1): 42–9. doi:10.1007/s00439-002-0832-1. PMID 12483298.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Liew CK, Simpson RJ, Kwan AH, et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583–8. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.
• Vannucchi AM, Pancrazzi A, Guglielmelli P, et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis". Am. J. Pathol. 167 (3): 849–58. doi:10.1016/S0002-9440(10)62056-1. PMC 1698737. PMID 16127162.
• Yang HY, Kim SH, Kim SH, et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells". Biochem. Biophys. Res. Commun. 353 (4): 978–84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.