ZFP161

Zinc finger protein 161 homolog is a protein that in humans is encoded by the ZFP161 gene.[5][6]

ZBTB14
Identifiers
Aliases	ZBTB14, ZF5, ZFP-161, ZFP-5, ZFP161, ZNF478, zinc finger and BTB domain containing 14
External IDs	OMIM: 602126 MGI: 1195345 HomoloGene: 2560 GeneCards: ZBTB14
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.31 Start 5,289,019 bp[1] End 5,297,053 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E1.3|17 40.42 cM Start 69,383,050 bp[2] End 69,391,199 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm • nucleolus • cytosol • aggresome Biological process • cardiac septum development • heart valve development • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • coronary vasculature development • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7541	22666
Ensembl	ENSG00000198081	ENSMUSG00000049672
UniProt	O43829	Q08376
RefSeq (mRNA)	NM_003409 NM_001143823 NM_001243702 NM_001243704	NM_009547 NM_001356282 NM_001356283
RefSeq (protein)	NP_001137295 NP_001230631 NP_001230633 NP_003400	NP_033573 NP_001343211 NP_001343212
Location (UCSC)	Chr 18: 5.29 – 5.3 Mb	Chr 17: 69.38 – 69.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Chromosome 18 (human)
• Sequence homology
• Zinc finger

References

1. GRCh38: Ensembl release 89: ENSG00000198081 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049672 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sobek-Klocke I, Disque-Kochem C, Ronsiek M, Klocke R, Jockusch H, Breuning A, Ponstingl H, Rojas K, Overhauser J, Eichenlaub-Ritter U (Sep 1997). "The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)". Genomics. 43 (2): 156–64. doi:10.1006/geno.1997.4784. PMID 9244432.
6. "Entrez Gene: ZFP161 zinc finger protein 161 homolog (mouse)".

Further reading

• Numoto M, Niwa O, Kaplan J, et al. (1993). "Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins". Nucleic Acids Res. 21 (16): 3767–75. doi:10.1093/nar/21.16.3767. PMC 309887. PMID 8367294.
• Sugiura K, Muro Y, Nagai Y, et al. (1997). "Expression cloning and intracellular localization of a human ZF5 homologue". Biochim. Biophys. Acta. 1352 (1): 23–6. doi:10.1016/s0167-4781(97)00045-6. PMID 9177479.
• Obata T, Yanagidani A, Yokoro K, et al. (1999). "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5". Biochem. Biophys. Res. Commun. 255 (2): 528–34. doi:10.1006/bbrc.1998.9970. PMID 10049742.
• Numoto M, Yokoro K, Koshi J (1999). "ZF5, which is a Kruppel-type transcriptional repressor, requires the zinc finger domain for self-association". Biochem. Biophys. Res. Commun. 256 (3): 573–8. doi:10.1006/bbrc.1999.0375. PMID 10080939.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lee KH, Kwak YD, Kim DH, et al. (2004). "Human zinc finger protein 161, a novel transcriptional activator of the dopamine transporter". Biochem. Biophys. Res. Commun. 313 (4): 969–76. doi:10.1016/j.bbrc.2003.11.183. PMID 14706637.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang J, Kudoh J, Takayanagi A, Shimizu N (2005). "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161". Biochem. Biophys. Res. Commun. 327 (2): 615–27. doi:10.1016/j.bbrc.2004.12.048. PMID 15629158.
• Orlov SV, Kuteĭkin-Tepliakov KB, Grishin AV, et al. (2006). "[Transcription factor ZF5 regulates expression of mammalian gene containing GCC-triplet repeats in 5'-regulatory region in human hepatoma HepG2 cells]". Tsitologiia. 48 (3): 246–52. PMID 16805315.
• Orlov SV, Kuteykin-Teplyakov KB, Ignatovich IA, et al. (2007). "Novel repressor of the human FMR1 gene - identification of p56 human (GCC)(n)-binding protein as a Krüppel-like transcription factor ZF5". FEBS J. 274 (18): 4848–62. doi:10.1111/j.1742-4658.2007.06006.x. PMID 17714511.