Zinc finger homeobox 2

Zinc finger homeobox 2 is a protein that in humans is encoded by the ZFHX2 gene.[5] It has been implicated in pain insensitivity.[6]

ZFHX2
Identifiers
Aliases	ZFHX2, ZFH-5, ZNF409, ZFH5, MARSIS, zinc finger homeobox 2
External IDs	OMIM: 617828 MGI: 2686934 HomoloGene: 52657 GeneCards: ZFHX2
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 23,520,857 bp[1] End 23,556,192 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 55,060,262 bp[2] End 55,092,324 bp[2]
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • zinc ion binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component • cell nucleus Biological process • adult behavior • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • regulation of sensory perception of pain Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85446	239102
Ensembl	ENSG00000136367	ENSMUSG00000040721
UniProt	Q9C0A1	Q2MHN3
RefSeq (mRNA)	NM_033400	NM_001039198
RefSeq (protein)	NP_207646	NP_001034287
Location (UCSC)	Chr 14: 23.52 – 23.56 Mb	Chr 14: 55.06 – 55.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136367 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040721 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger homeobox 2".
6. Habib AM, Matsuyama A, Okorokov AL, Santana-Varela S, Bras JT, Aloisi AM, et al. (December 2017). "A novel human pain insensitivity disorder caused by a point mutation in ZFHX2" (PDF). Brain. 141 (2): 365–376. doi:10.1093/brain/awx326. PMC 5837393. PMID 29253101.