ZDHHC17

Palmitoyltransferase ZDHHC17 is an enzyme that contains a DHHC domain that in humans is encoded by the ZDHHC17 gene.[5][6][7]

ZDHHC17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EU9
Identifiers
Aliases	ZDHHC17, HIP14, HIP3, HYPH, HSPC294, zinc finger DHHC-type containing 17, DHHC-17, zinc finger DHHC-type palmitoyltransferase 17
External IDs	OMIM: 607799 MGI: 2445110 HomoloGene: 56324 GeneCards: ZDHHC17
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.2 Start 76,763,588 bp[1] End 76,853,696 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 110,941,780 bp[2] End 111,010,140 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein-cysteine S-palmitoyltransferase activity • transferase activity • magnesium ion transmembrane transporter activity • signal transducer activity • palmitoyltransferase activity • GO:0001948 protein binding • identical protein binding • transferase activity, transferring acyl groups Cellular component • integral component of membrane • Golgi apparatus • intracellular membrane-bounded organelle • membrane • Golgi membrane • Golgi-associated vesicle membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • presynaptic membrane • cell membrane • synapse • cell junction • cytosol Biological process • protein palmitoylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • lipoprotein transport • signal transduction • magnesium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23390	320150
Ensembl	ENSG00000186908	ENSMUSG00000035798
UniProt	Q8IUH5	Q80TN5
RefSeq (mRNA)	NM_015336 NM_001359626	NM_172554 NM_001359622 NM_001359624
RefSeq (protein)	NP_056151 NP_001346555	NP_766142 NP_001346551 NP_001346553
Location (UCSC)	Chr 12: 76.76 – 76.85 Mb	Chr 10: 110.94 – 111.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ZDHHC17 has been shown to interact with Huntingtin.[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000186908 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035798 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
6. Goytain A, Hines RM, Quamme GA (Nov 2008). "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport". The Journal of Biological Chemistry. 283 (48): 33365–74. doi:10.1074/jbc.M801469200. PMC 2662264. PMID 18794299.
7. "Entrez Gene: ZDHHC17 zinc finger, DHHC-type containing 17".
8. Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
9. Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics. 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD (Dec 2004). "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase". Oncogene. 23 (57): 9230–7. doi:10.1038/sj.onc.1208171. PMC 2908390. PMID 15489887.
• Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A (Dec 2004). "Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins". Neuron. 44 (6): 977–86. doi:10.1016/j.neuron.2004.11.027. PMID 15603740.