YqeY protein domain

In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the production of charged transfer RNA used in the process of translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase (GlnRS) in almost all eukaryotes.[1]

YqeY
Structure of cytosolic protein of unknown function YqeY from Bacillus subtilis
Identifiers
SymbolYqeY
PfamPF09424
Pfam clanCL0279
InterProIPR019004
SCOPe1ng5 / SUPFAM

Function

The YqeY domain has been found to be involved in the recognition of tRNA charged with the amino acid glutamine (tRNA-Gln).[1] In some cases YqeY also increases the affinity of GlnRS for tRNA-Gln, but only when present in cis (that is, as part of the GlnRS polypeptide chain). However, the presence of YqeY as a standalone domain in organisms without GlnRS suggests that YqeY domains may have additional cellular functions.[2]

Homology

This protein domain shares sequence homology with the C-terminal domain of GatB and GatE, the tRNA-binding subunits of bacterial and archaeal glutamine amidotransferases.[2]

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gollark: They actually loop around after 107 iterations.
gollark: Also in the GTech™ GAfterlife²™.
gollark: A somewhat worse version of this MAY be incorporated into ABR at any time.
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References
  1. Hadd, A; Perona, JJ (23 October 2014). "Coevolution of specificity determinants in eukaryotic glutamyl- and glutaminyl-tRNA synthetases". Journal of Molecular Biology. 426 (21): 3619–33. doi:10.1016/j.jmb.2014.08.006. PMID 25149203.
  2. Deniziak M, Sauter C, Becker HD, Paulus CA, Giegé R, Kern D (2007). "Deinococcus glutaminyl-tRNA synthetase is a chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation". Nucleic Acids Res. 35 (5): 1421–31. doi:10.1093/nar/gkl1164. PMC 1865053. PMID 17284460.
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