Yoda1

Yoda1
Names
	IUPAC name 2-[5-([(2,6-Dichlorophenyl)methyl]thio)-1,3,4-thiadiazol-2-yl]pyrazine
Identifiers
CAS Number	448947-81-7 ;
3D model (JSmol)	Interactive image;
PubChem CID	2746822;
	SMILES ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1;
Properties
Chemical formula	C13H8Cl2N4S2
Molar mass	355.27 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Yoda1 is a chemical compound which is the first agonist developed for the mechanosensitive ion channel PIEZO1. This protein is involved in regulation of blood pressure and red blood cell volume, and Yoda1 is used in scientific research in these areas.[1][2][3][4][5]

References

Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A. Chemical activation of the mechanotransduction channel Piezo1. eLife. 2015 May 22;4. doi: 10.7554/eLife.07369 PMID 26001275
Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A. Piezo1 links mechanical forces to red blood cell volume. eLife. 2015 May 22;4:e07370. doi: 10.7554/eLife.07370 PMID 26001274
Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. Journal of clinical investigation. 2016 Dec 1;126(12):4527. doi: 10.1172/JCI87343. PMID 27797339
Rapetti-Mauss R, Picard V, Guitton C, Ghazal K, Proulle V, Badens C, Soriani O, Garçon L, Guizouarn H. Red blood cell Gardos channel (KCNN4): the essential determinant of erythrocyte dehydration in Hereditary Xerocytosis. Haematologica. 2017 Jun 15:haematol-2017.
Gnanasambandam R, Gottlieb PA, Sachs F. The Kinetics and the Permeation Properties of Piezo Channels. Curr Top Membr. 2017;79:275-307. doi: 10.1016/bs.ctm.2016.11.004. PMID 28728821

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[1] Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A. Chemical activation of the mechanotransduction channel Piezo1. eLife. 2015 May 22;4. doi: 10.7554/eLife.07369 PMID 26001275

[2] Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A. Piezo1 links mechanical forces to red blood cell volume. eLife. 2015 May 22;4:e07370. doi: 10.7554/eLife.07370 PMID 26001274

[3] Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. Journal of clinical investigation. 2016 Dec 1;126(12):4527. doi: 10.1172/JCI87343. PMID 27797339

[4] Rapetti-Mauss R, Picard V, Guitton C, Ghazal K, Proulle V, Badens C, Soriani O, Garçon L, Guizouarn H. Red blood cell Gardos channel (KCNN4): the essential determinant of erythrocyte dehydration in Hereditary Xerocytosis. Haematologica. 2017 Jun 15:haematol-2017.

[5] Gnanasambandam R, Gottlieb PA, Sachs F. The Kinetics and the Permeation Properties of Piezo Channels. Curr Top Membr. 2017;79:275-307. doi: 10.1016/bs.ctm.2016.11.004. PMID 28728821