YTHDF2

YTH N6-methyladenosine RNA binding protein 2 is a protein that in humans is encoded by the YTHDF2 gene. [5]

YTHDF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RDN, 4RDO, 4WQN
Identifiers
Aliases	YTHDF2, HGRG8, NY-REN-2, CAHL, YTH N6-methyladenosine RNA binding protein 2
External IDs	OMIM: 610640 MGI: 2444233 HomoloGene: 32302 GeneCards: YTHDF2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,736,621 bp[1] End 28,769,775 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,184,912 bp[2] End 132,212,303 bp[2]
Gene ontology Molecular function • N6-methyladenosine-containing RNA binding • GO:0001948 protein binding • RNA binding Cellular component • cytosol • P-body • cell nucleus • cytoplasm • microtubule organizing center • cytoplasmic ribonucleoprotein granule Biological process • humoral immune response • positive regulation of cap-independent translational initiation • regulation of mRNA stability • embryonic morphogenesis • mRNA destabilization • oocyte maturation • negative regulation of Notch signaling pathway • endothelial to hematopoietic transition • regulation of hematopoietic stem cell differentiation • regulation of meiotic cell cycle process involved in oocyte maturation • cell differentiation • oogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51441	213541
Ensembl	ENSG00000198492	ENSMUSG00000040025
UniProt	Q9Y5A9	Q91YT7
RefSeq (mRNA)	NM_016258 NM_001172828 NM_001173128	NM_145393
RefSeq (protein)	NP_001166299 NP_001166599 NP_057342	NP_663368
Location (UCSC)	Chr 1: 28.74 – 28.77 Mb	Chr 4: 132.18 – 132.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline-rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively, spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012].

See also

N⁶-Methyladenosine

References

1. GRCh38: Ensembl release 89: ENSG00000198492 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040025 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: YTH N6-methyladenosine RNA binding protein 2". Retrieved 2017-12-24.

Further reading

• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C (2006). "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. doi:10.1093/gerona/61.6.547. PMID 16799135.
• Cardelli M, Marchegiani F, Cavallone L, Olivieri F, Giovagnetti S, Mugianesi E, Moresi R, Lisa R, Franceschi C (2006). "A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity". J. Gerontol. A Biol. Sci. Med. Sci. 61 (6): 547–56. doi:10.1093/gerona/61.6.547. PMID 16799135.
• Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, Ren B, Pan T, He C (2014). "N6-methyladenosine-dependent regulation of messenger RNA stability". Nature. 505 (7481): 117–20. doi:10.1038/nature12730. PMC 3877715. PMID 24284625.
• Li F, Zhao D, Wu J, Shi Y (2014). "Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition". Cell Res. 24 (12): 1490–2. doi:10.1038/cr.2014.153. PMC 4260351. PMID 25412658.
• Zhu T, Roundtree IA, Wang P, Wang X, Wang L, Sun C, Tian Y, Li J, He C, Xu Y (2014). "Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine". Cell Res. 24 (12): 1493–6. doi:10.1038/cr.2014.152. PMC 4260350. PMID 25412661.
• Xu C, Liu K, Ahmed H, Loppnau P, Schapira M, Min J (2015). "Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins". J. Biol. Chem. 290 (41): 24902–13. doi:10.1074/jbc.M115.680389. PMC 4598999. PMID 26318451.
• Tirumuru N, Zhao BS, Lu W, Lu Z, He C, Wu L (2016). "N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression". eLife. 5. doi:10.7554/eLife.15528. PMC 4961459. PMID 27371828.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.